Evidence map›Paper›PMID 37215013›Full record

ArticlebioRxiv : the preprint server for biology2023

Elevated nuclear TDP-43 induces constitutive exon skipping.

Rogger P Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R Sinha, Koping Chang, Vickie Trinh, William Chung, Kyra Bowden, Juan C Troncoso, Seth Blackshaw and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Rogger P Carmen-OrozcoDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
William TsaoDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Yingzhi YeDepartment of Physiology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Irika R SinhaDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Koping ChangDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Vickie TrinhDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
William ChungDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Kyra BowdenDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Juan C TroncosoDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Seth BlackshawDepartment of Neuroscience Johns Hopkins School of Medicine, Baltimore, MD 21205.
Lindsey R HayesDepartment of Neurology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Shuying SunDepartment of Physiology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Philip C WongDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Jonathan P LingDepartment of Pathology Johns Hopkins School of Medicine, Baltimore, MD 21205.
Johns Hopkins University · US

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Single molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTDRF1NS113820 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING, WU, BIN · 2020 to 2025
$6.2M
RNA-based regulation of TDP-43 nuclear export in ALS/FTDR01NS123538 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HOKE, AHMET · 2021 to 2025
$2.4M
TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and BiomarkerR01NS095969 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PHILIP C WONG · 2016 to 2026
$2.4M
Molecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTDR01NS107347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2018 to 2022
$1.8M
Generation of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous systemRF1MH123237 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2020 to 2020
$1.5M
Dysregulation of inhibitory synapse by poly-GR in C9ORF72-ALS/FTDR21AG072078 · NIA · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2021 to 2021
$450k
NIA NIH HHS P30 AG066507NIA NIH HHS R21 AG072078NIA NIH HHS U19 AG033655NIMH NIH HHS RF1 MH123237NINDS NIH HHS R01 NS095969NINDS NIH HHS R01 NS107347NINDS NIH HHS R01 NS123538NINDS NIH HHS RF1 NS113820
6 · The paper itself

Abstract

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate

Identifiers

PMID37215013
PMCPMC10197708
OpenAlexW4376272481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.