Evidence map›Paper›PMID 37214986›Full record

ArticlebioRxiv : the preprint server for biology2023

RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome-wide.

Jeremy W Schroeder, Rebecca L Hurto, Justin R Randall, Katherine J Wozniak, Taylor A Timko, Taylor M Nye, Jue D Wang, Peter L Freddolino, Lyle A Simmons

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jeremy W SchroederDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109.
Rebecca L HurtoDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109.
Justin R RandallDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Katherine J WozniakDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Taylor A TimkoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Taylor M NyeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Jue D WangDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706.
Peter L FreddolinoDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109.
Lyle A SimmonsDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Cellular Biotechnology Training Program (CBTP)T32GM008353 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 1991 to 2021
$9.3M
The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteriaR35GM127088 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jue D. Wang · 2018 to 2026
$3.9M
Building a unified framework for understanding bacterial gene regulation and chromosomal architectureR35GM128637 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lydia Petra Freddolino · 2018 to 2026
$3.6M
Novel mechanisms of DNA repair and cell cycle regulation in bacteriaR35GM131772 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lyle Simmons · 2019 to 2026
$2.8M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
NIGMS NIH HHS R35 GM127088NIGMS NIH HHS R35 GM128637NIGMS NIH HHS R35 GM131772NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32 GM008353NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

rnaDNA hybrids such as R-loops affect genome integrity and DNA replication fork progression. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative effects of hybrids, remain unknown. Here, we investigate the contributions of RNases HII (RnhB) and HIII (RnhC) to hybrid removal, DNA replication, and mutagenesis genome-wide. Deletion of either

Identifiers

PMID37214986
PMCPMC10197577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.