Evidence map›Paper›PMID 37214936›Full record

ArticlebioRxiv : the preprint server for biology2023

Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neurons.

Hui-Quan Li, Wuji Jiang, Lily Ling, Vaidehi Gupta, Cong Chen, Marta Pratelli, Swetha K Godavarthi, Nicholas C Spitzer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hui-Quan LiNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Wuji JiangNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Lily LingNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Vaidehi GuptaNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Cong ChenDepartment of Cellular and Molecular Medicine, University of California, San Diego.
Marta PratelliNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Swetha K GodavarthiNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
Nicholas C SpitzerNeurobiology Department and Kavli Institute for Brain and Mind, University of California, San Diego.
University of California San Diego · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Determining Fundamental Properties of Neurotransmitter Switching in Adult MammalsR35NS116810 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NICHOLAS CANADAY SPITZER · 2020 to 2026
$4.2M
NINDS NIH HHS P30 NS047101NINDS NIH HHS R35 NS116810
6 · The paper itself

Abstract

Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. Here we show that generalized fear in mice in response to footshock results from a transmitter switch from glutamate to GABA in serotonergic neurons of the lateral wings of the dorsal raphe. We observe a similar change in transmitter identity in the postmortem brains of PTSD patients. Overriding the transmitter switch in mice using viral tools prevents the acquisition of generalized fear. Corticosterone release and activation of glucocorticoid receptors trigger the switch, and prompt antidepressant treatment blocks the co-transmitter switch and generalized fear. Our results provide new understanding of the plasticity involved in fear generalization.

Identifiers

PMID37214936
PMCPMC10197626
OpenAlexW4376141744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.