Evidence map›Paper›PMID 37214931›Full record

ArticlebioRxiv : the preprint server for biology2023

Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimer's disease neuropathology in a mouse model.

Chiara Criscuolo, Elissavet Chartampila, Stephen D Ginsberg, Helen E Scharfman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chiara CriscuoloCenter for Dementia Research, the Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA.
Elissavet ChartampilaCenter for Dementia Research, the Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA.
Stephen D GinsbergCenter for Dementia Research, the Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA.
Helen E ScharfmanCenter for Dementia Research, the Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA.
Nathan Kline Institute for Psychiatric Research · USUniversity of North Carolina at Chapel Hill · US

Funding

Septhohippocamal connectome dysfunction in Down syndrome associated with Alzheimer’s disease pathophysiologyRF1AG077103 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GINSBERG, STEPHEN D, STUTZMANN, GRACE E. · 2023 to 2023
$2.5M
Hyperexcitability in Alzheimer's DiseaseR01AG055328 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2017 to 2021
$2.0M
Hyperexcitability in Alzheimer's DiseaseRF1AG055328 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Helen E Scharfman · 2024 to 2026
$2.0M
NIA NIH HHS R01 AG055328NIA NIH HHS RF1 AG055328NIA NIH HHS RF1 AG077103
6 · The paper itself

Abstract

The neurotrophin brain-derived neurotrophic factor (BDNF) is important in development and maintenance of neurons and their plasticity. Hippocampal BDNF has been implicated Alzheimer's disease (AD) because hippocampal levels in AD patients and AD animal models are consistently downregulated, suggesting that reduced BDNF contributes to AD. However, the location where hippocampal BDNF protein is most highly expressed, the mossy fiber (MF) axons of dentate gyrus (DG) granule cells (GCs), has been understudied, and never in controlled

Identifiers

PMID37214931
PMCPMC10197599
OpenAlexW4375852133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.