Evidence map›Paper›PMID 37214909›Full record

ArticlebioRxiv : the preprint server for biology2023

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.

Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K Oliveira, John R Lukens, Andrés Norambuena, James W Mandell, George S Bloom

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xuehan SunDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Guillermo EastmanDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Yu ShiDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Subhi SaibabaDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Ana K OliveiraDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
John R LukensDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Andrés NorambuenaDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
James W MandellDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
George S BloomDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
University of Virginia · USMinisterio de Educación y Cultura · UY

Funding

Linking Tau Structure to Its Functions and Mechanisms in Alzheimer’s DiseaseRF1AG051085 · NIA · UNIVERSITY OF VIRGINIA · PI BLOOM, GEORGE S · 2016 to 2016
$1.8M
NIA NIH HHS RF1 AG051085
6 · The paper itself

Abstract

introductionNeuronal nuclei are normally smoothly surfaced. In Alzheimer's disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauopathies.

methodsNuclear invagination was assayed by immunofluorescence in brain, and in cultured neurons before and after extracellular tau oligomers (xcTauO) exposure. Nucleocytoplasmic transport was assayed in cultured neurons. Gene expression was investigated using nanoString nCounter technology and qRT-PCR.

resultsInvaginated nuclei were twice as abundant in human AD as in cognitively normal adults, and were increased in mouse neurodegeneration models. In cultured neurons, nuclear invagination was induced by xcTauOs by an intracellular tau-dependent mechanism. xcTauOs impaired nucleocytoplasmic transport, increased histone H3 trimethylation at lysine 9 and altered gene expression, especially by increasing tau mRNA. DISCUSSION: xcTauOs may be a primary cause of nuclear invagination

Indexed as

Alzheimer’s diseasenuclear invaginationtau oligomers

Identifiers

PMID37214909
PMCPMC10197541
OpenAlexW4375851330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.