Evidence map›Paper›PMID 37214825›Full record

ArticlebioRxiv : the preprint server for biology2023

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism.

Sunada Khadka, Yu-Hsi Lin, Jeffrey Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Behr, Yasaman Barekatain and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Sunada KhadkaDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yu-Hsi LinDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeffrey AckroydDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yi-An ChenCancer and Cell Biology Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Yanghui ShengCrown Bioscience Inc., Suzhou Industrial Park, 218 Xinghu Rd, Jiangsu, China.
Wubin QianCrown Bioscience Inc., Suzhou Industrial Park, 218 Xinghu Rd, Jiangsu, China.
Sheng GuoCrown Bioscience Inc., Suzhou Industrial Park, 218 Xinghu Rd, Jiangsu, China.
Yining ChenDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Eliot BehrDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yasaman BarekatainDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nasir UddinDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kenisha ArthurDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Victoria YanDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wen-Hao HsuDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Qing ChangDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anton PoralDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Theresa TranDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Surendra ChaurasiaDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dimitra K GeorgiouDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John M AsaraDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Floris P BarthelCancer and Cell Biology Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Steve W MillwardDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ronald A DePinhoDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Florian L MullerDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USCrown Bioscience (China) · CNTranslational Genomics Research Institute · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
Pro-Drug Enolase Inhibitors in Precision OncologyR01CA231509 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLWARD, STEVEN W · 2021 to 2025
$1.6M
Collateral Deletions Expose Targetable Metabolic Vulnerabilities in the PTEN locusR21CA226301 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MULLER, FLORIAN · 2018 to 2019
$378k
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA231509NCI NIH HHS R21 CA226301
6 · The paper itself

Abstract

Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the tumor of oxygen and essential nutrients, cancer cells activate metabolic adaptations to diminish therapeutic response. Despite these adaptations, angiogenesis inhibition incurs extensive metabolic stress, prompting us to consider such metabolic stress as an

Identifiers

PMID37214825
PMCPMC10197573
OpenAlexW4376113923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.