Evidence map›Paper›PMID 37214545›Full record

ReviewMaterials today. Bio2023

Functionalization of biomimetic mineralized collagen for bone tissue engineering.

Xiujie Zhu, Chenyu Wang, Haotian Bai, Jiaxin Zhang, Zhonghan Wang, Zuhao Li, Xin Zhao, Jincheng Wang, He Liu

Open access · goldAbstract readReview
In one paragraph

Review in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  15. Application of collagen in bone regeneration.Journal of orthopaedic translation · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiujie ZhuDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Chenyu WangDepartment of Plastic and Reconstruct Surgery, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, PR China.
Haotian BaiDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Jiaxin ZhangDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Zhonghan WangDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Zuhao LiDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Xin ZhaoDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Jincheng WangDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
He LiuDepartment of Orthopedics, The Second Hospital of Jilin University, 4110 Yatai Street, Changchun, 130041, PR China.
Second Affiliated Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mineralized collagen (MC) is the basic unit of bone structure and function and is the main component of the extracellular matrix (ECM) in bone tissue. In the biomimetic method, MC with different nanostructures of neo-bone have been constructed. Among these, extra-fibrous MC has been approved by regulatory agencies and applied in clinical practice to play an active role in bone defect repair. However, in the complex microenvironment of bone defects, such as in blood supply disorders and infections, MC is unable to effectively perform its pro-osteogenic activities and needs to be functionalized to include osteogenesis and the enhancement of angiogenesis, anti-infection, and immunomodulation. This article aimed to discuss the preparation and biological performance of MC with different nanostructures in detail, and summarize its functionalization strategy. Then we describe the recent advances in the osteo-inductive properties and multifunctional coordination of MC. Finally, the latest research progress of functionalized biomimetic MC, along with the development challenges and future trends, are discussed. This paper provides a theoretical basis and advanced design philosophy for bone tissue engineering in different bone microenvironments.

Indexed as

Bioactive factorsBiomimeticBone tissue repairFunctionalizationMineralized collagenOsteogenesis

Identifiers

PMID37214545
PMCPMC10199226
OpenAlexW4372337939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.