Is Combining Two Different Routes of TXA Administration an Effective Blood Conserving Strategy for Total Knee Arthroplasty.

Aim: To evaluate the efficacy of combined use of pre-operative oral and post-operative intravenous (IV) tranexamic acid (TXA) as an effective blood conserving regimen in total knee arthroplasty (TKA) and compare its outcome with other modes of TXA administration. Patients and Methods: A prospective observational study was conducted on 25 patients with osteoarthritis knee undergoing TKA. Patients were given 1950 mg of oral TXA pre-operatively and 15 mg/kg of IV TXA post-operatively before tourniquet deflation. The outcome of the study in terms of peri-operative (intra-operative and post-operative) blood loss estimation, drain output, percentage fall in haemoglobin, and knee HSS scores pre-operatively and on subsequent follow-up were compared with the outcome of previous studies conducted in the same institution with intra-operative topical TXA administration, pre-operative oral TXA administration and without TXA administration. Results: The mean drain volume was 307.30 ± 148.00 ml and 22 (88%) patients had a drain volume less than 500 ml. The mean post-operative haemoglobin value was 10.53 ± 1.75 g/dl. It was observed that 18 (72%) of patients had up to 15% fall in haemoglobin. The mean percentage fall was 11.92%. In this study, 22 (88%) patients did not require any blood transfusion. Mean blood loss was 369.6 ± 159.96 ml. Maximum patients had less than 500 ml blood loss. No incidence of implant loosening, infection or wound gaping, clinically evident DVT/pulmonary thromboembolism was observed in the present study. We analysed total modified HSS knee score from pre-operative to 6 months follow-up using multi-group repeated measures analysis of variance (ANOVA), the difference in total modified HSS knee score between all the duration was observed to be highly significant ( Discussion: Combined administration of pre-operative oral and post-operative IV TXA is a safe and effective blood-conserving strategy in patients undergoing TKA along with the use of tourniquet. The outcome in terms of post-operative blood loss and drain output and the knee HSS score is comparable to the other modes of administration. Supplementary Information: The online version contains supplementary material available at 10.1007/s43465-023-00875-w.