Evidence map›Paper›PMID 37214333›Full record

ArticleFunction (Oxford, England)2023

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with K

Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Bayliss-Starling Prize Lecture: KThe Journal of physiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Overactive ATP-Sensitive KFunction (Oxford, England) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia MO 65212, USA.ORCID 0000-0002-7992-9300
Jorge A Castorena-GonzalezDepartment of Pharmacology, Tulane University School of Medicine, New Orleans LA 70112, USA.
Hae Jin KimDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia MO 65212, USA.
Min LiDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia MO 65212, USA.
Maria RemediCenter for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Colin G NicholsCenter for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-4929-2134
University of Missouri · USWashington University in St. Louis · USTulane University · US

Funding

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaR35HL140024 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2018 to 2023
$5.9M
KATP channels and lymphatic dysfunction in Cantu SyndromeR01HL141107 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL141107NHLBI NIH HHS R35 HL140024
6 · The paper itself

Abstract

Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of K

Indexed as

Gain of Function MutationKATP ChannelsAdenosine TriphosphateAnimalsCardiomegalyHypertrichosisMiceMutationOsteochondrodysplasiasAdenosine TriphosphateKATP ChannelsglibenclamideKir6.1lymphatic pumpingprimary lymphedemasmooth muscle excitabilitySUR2

Identifiers

PMID37214333
PMCPMC10194823
OpenAlexW4366426970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.