Evidence map›Paper›PMID 37213814›Full record

ArticleToxicology reports2023

Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12

Bozhidar Baltov, Stanislav Beyl, Igor Baburin, Jakob Reinhardt, Phillip Szkokan, Aleksandra Garifulina, Eugen Timin, Udo Kraushaar, Olivier Potterat, Matthias Hamburger and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Bozhidar BaltovDivision of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Stanislav BeylChanPharm GmbH, Am Kanal 27, 1110 Vienna, Austria.
Igor BaburinChanPharm GmbH, Am Kanal 27, 1110 Vienna, Austria.
Jakob ReinhardtPharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Phillip SzkokanChanPharm GmbH, Am Kanal 27, 1110 Vienna, Austria.
Aleksandra GarifulinaDivision of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Eugen TiminChanPharm GmbH, Am Kanal 27, 1110 Vienna, Austria.
Udo KraushaarNMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany.
Olivier PotteratPharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Matthias HamburgerPharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Philipp KüglerUniversity of Hohenheim, Institute of Applied Mathematics and Statistics and Computational Science Hub, 70599 Stuttgart, Germany.
Steffen HeringDivision of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
University of Basel · CHUniversity of Vienna · ATNatural and Medical Sciences Institute · DEUniversity of Hohenheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of proarrhythmic effects of herbal products. Here, we propose a cardiac safety assay for the detection of proarrhythmic effects of plant extracts based on the experimental approaches described in the Comprehensive

Indexed as

Cardiac safetyEvodia rutaecarpaHERGHiPSC-CMsTdP

Identifiers

PMID37213814
PMCPMC10196857
OpenAlexW4367057088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.