Evidence map›Paper›PMID 37213666›Full record

ArticleInternational journal of medical sciences2023

Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.

Kuen-Daw Tsai, Yi-Chao Lee, Bo-Yu Chen, Li-Syuan Wu, Shan-Yuan Liang, Ming-Yuan Liu, Yu-Wen Hung, Hui-Ling Hsu, Pei-Qi Chen, Jia-Ching Shieh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kuen-Daw TsaiDepartment of Internal Medicine, China Medical University Beigang Hospital, 123 Sinde Road, Beigang Township, Yunlin County, 65152, Taiwan, ROC.
Yi-Chao LeePh.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.
Bo-Yu ChenSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Li-Syuan WuSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Shan-Yuan LiangSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Ming-Yuan LiuSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Yu-Wen HungSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Hui-Ling HsuDepartment of Respiratory Therapy, China Medical University Beigang Hospital, 123 Sinde Road, Beigang Township, Yunlin County, 65152, Taiwan, ROC.
Pei-Qi ChenSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Jia-Ching ShiehSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Yi-Ju LeeInstitute of Medicine, Chung Shan Medical University, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Ting-Hui LinSchool of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University; Department of Medical Research, Chung Shan Medical University Hospital, 110 Jianguo North Road, Section 1, Taichung 40203, Taiwan, ROC.
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) is an IFNγ-inducible protein that modulates cellular dNTP levels. Mutations in the human

Indexed as

Lupus NephritisNF-kappa BCells, CulturedHumansInterferon-gammaInterferon gamma ReceptorKlotho ProteinsMesangial CellsSAM Domain and HD Domain-Containing Protein 1Interferon-gammaInterferon gamma ReceptorKlotho ProteinsKL protein, humanNF-kappa BSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanglomerular mesangial cellsIFNγJAK-STAT1KlothoNFκBSAMHD1

Identifiers

PMID37213666
PMCPMC10198147
OpenAlexW4372047026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.