Evidence map›Paper›PMID 37213664›Full record

ArticleJournal of oral microbiology2023

SARS-CoV-2 RT-qPCR Ct values in saliva and nasopharyngeal swab samples for disease severity prediction.

Kristina Snipaitiene, Birute Zablockiene, Rasa Sabaliauskaite, Kristina Zukauskaite, Elzbieta Matulyte, Tautvile Smalinskaite, Mindaugas Paulauskas, Rolandas Zablockis, Mantvydas Lopeta, Julius Gagilas and 3 more

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kristina SnipaitieneInstitute of Biomedical Sciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-9766-7108
Birute ZablockieneCenter of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-8519-6265
Rasa SabaliauskaiteLaboratory of Genetic Diagnostic, National Cancer Institute of Lithuania, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-3465-3558
Kristina ZukauskaiteInstitute of Biomedical Sciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-8707-6598
Elzbieta MatulyteCenter of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-4400-9547
Tautvile SmalinskaiteFaculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-9465-3464
Mindaugas PaulauskasCenter of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-9671-4053
Rolandas ZablockisClinic of Chest Diseases, Immunology and Allergology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-0411-828X
Mantvydas LopetaJSC Diagnolita, Vilnius, Lithuania.ORCID https://orcid.org/0000-0002-8674-8989
Julius GagilasJSC Diagnolita, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-6483-1645
Alina PurieneInstitute of Odontology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-6917-3039
Ligita JancorieneCenter of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-6488-6312
Sonata JarmalaiteInstitute of Biomedical Sciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0003-3719-0891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Comparison of clinical value of RT-qPCR-based SARS-CoV-2 tests performed on saliva samples (SSs) and nasopharyngeal swab samples (NPSs) for prediction of the COVID-19 disease severity. Methods: Three paired SSs and NPSs collected every 3 days from 100 hospitalised COVID-19 patients during 2020 Jul-2021 Jan were tested by RT-qPCR for the original SARS-CoV-2 virus and compared to 150 healthy controls. Cases were divided into mild+moderate (Cohort I, Results: SARS-CoV-2 was detected in 65% (91/140) vs. 53% (82/156) of NPSs and 49% (68/139) vs. 48% (75/157) of SSs collected from Cohort I and II, respectively, resulting in the total respective detection rates of 58% (173/296) vs. 48% (143/296) ( Conclusion: Salivary RT-qPCR testing is suitable for SARS-CoV-2 infection control, while simple measurement of Ct values can assist in prediction of COVID-19 severity.

Indexed as

COVID-19Ct valuesRT-qPCRsalivaSARS-CoV-2severityviral dynamics

Identifiers

PMID37213664
PMCPMC10193917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.