Evidence map›Paper›PMID 37213564›Full record

ArticleNeurosurgery practice2023

Brain Circuitry of Consciousness: A Review of Current Models and a Novel Synergistic Model With Clinical Application.

Theresa C Gammel, Leor N Alkadaa, Jordan R Saadon, Sabir Saluja, John Servider, Nathaniel A Cleri, Michael Egnor, Raphael P Davis, Chuan Huang, Yuri B Saalmann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Theresa C GammelDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Leor N AlkadaaDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Jordan R SaadonDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0001-5721-8332
Sabir SalujaDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
John ServiderDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Nathaniel A CleriDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Michael EgnorDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Raphael P DavisDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Chuan HuangDepartment of Radiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Yuri B SaalmannDepartment of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-8880-6698
Sima MofakhamDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0002-4509-6080
Charles B MikellDepartment of Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0002-0701-2325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How consciousness arises in the brain has important implications for clinical decision-making. We summarize recent findings in consciousness studies to provide a toolkit for clinicians to assess deficits in consciousness and predict outcomes after brain injury. Commonly encountered disorders of consciousness are highlighted, followed by the clinical scales currently used to diagnose them. We review recent evidence describing the roles of the thalamocortical system and brainstem arousal nuclei in supporting awareness and arousal and discuss the utility of various neuroimaging studies in evaluating disorders of consciousness. We explore recent theoretical progress in mechanistic models of consciousness, focusing on 2 major models, the global neuronal workspace and integrated information theory, and review areas of controversy. Finally, we consider the potential implications of recent research for the day-to-day decision-making of clinical neurosurgeons and propose a simple "three-strikes" model to infer the integrity of the thalamocortical system, which can guide prognosticating return to consciousness.

Indexed as

ConsciousnessGlobal neuronal workspaceIntegrated information theoryThalamocortical loopTraumatic brain injury

Identifiers

PMID37213564
PMCPMC10193831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.