Evidence map›Paper›PMID 37213429›Full record

ArticleOpen forum infectious diseases2023

Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine.

Isabelle de Malliard, Anne-Laure Houist, Gilles Peytavin, Thomas L'Yavanc, Magali Bouvier, Pierre Cappy, Jean-Daniel Lelièvre, Elsa Feredj, William Vindrios, Sebastien Gallien and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Virological Failure After Switch to Long-Acting Cabotegravir and Rilpivirine Injectable Therapy: An In-depth Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Isabelle de MalliardDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Anne-Laure HouistDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Gilles PeytavinInfection Antimicrobials Modelling Evolution, Inserm, Université de Paris, Paris, France.ORCID https://orcid.org/0000-0002-4359-537X
Thomas L'YavancPosthospitalization and Rehabilitation Unit, Hôpital Jean Jaurés, Paris, France.
Magali BouvierDepartment of Virology, Henri Mondor Hospital, Créteil, France.
Pierre CappyDepartment of Virology, Henri Mondor Hospital, Créteil, France.
Jean-Daniel LelièvreDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Elsa FeredjDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
William VindriosDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Sebastien GallienDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Giovanna MelicaDepartment of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Assistance Publique – Hôpitaux de Paris · FRHôpital Jean Jaurès · FRInserm · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m

Indexed as

adipocyte trappinggynecoid fat distributionHIV infectionintramuscular long-acting antiretroviral drugsvirological failure

Identifiers

PMID37213429
PMCPMC10199109
OpenAlexW4367852793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.