SynthesisWorld journal of gastroenterology2023
Different types of fruit intake and colorectal cancer risk: A meta-analysis of observational studies.
Synthesis in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Nutrition as Modulator of Oxidative Stress in Cancer Prevention and Treatment.International journal of molecular sciences · 2026Review
- Annurca Apple Extract and Colorectal Cancer Prevention: Preliminary In Silico Evaluation of Chlorogenic Acid.Diseases (Basel, Switzerland) · 2026Article
- Antiproliferative and Pro-Apoptotic Effects ofMetabolites · 2025Article
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- Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer.International journal of surgery (London, England) · 2025Review
- Risk factors, prevention and screening of colorectal cancer: A rising problem.World journal of gastroenterology · 2025Review
- Common Risk Factors in Gastrointestinal Cancers: A Narrative Review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Machine Learning Radiomics for Predicting Response to MR-Guided Radiotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Cohort Study.Journal of hepatocellular carcinoma · 2025Article
- Interplay Between Dietary Phytochemicals and Gut Microbiota in Colorectal Cancer: Future Directions and Considerations.Journal of nutrition and metabolism · 2025Review
- The association between fruit and vegetable intake and gastrointestinal cancers risk from Mendelian randomization analysis.Scientific reports · 2024Article
- Preliminary Assessment of the Protective and Antitumor Effects of Several Phytoene-Containing Bacterial and Microalgal Extracts in Colorectal Cancer.Molecules (Basel, Switzerland) · 2024Article
- Association of healthy diet score and adiposity with risk of colorectal cancer: findings from the UK Biobank prospective cohort study.European journal of nutrition · 2024Article
- Recommendations for articles and reviews in colorectal cancer-related research at the year-end of 2023.World journal of gastroenterology · 2024Article
- Nine dietary habits and risk of colorectal cancer: a Mendelian randomization study.BMC medical genomics · 2024Article
- A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple studies investigating the relationship between intake of different types of fruit and colorectal cancer (CRC) risk have yielded inconsistent results.
aimTo perform a meta-analysis of existing studies to assess the association between the intake of different kinds of fruit and the incidence of CRC.
methodsWe searched online literature databases including PubMed, Embase, WOS, and Cochrane Library for relevant articles available up to August 2022. With data extracted from observational studies, odds ratios (ORs) with 95% confidence intervals (CIs) were assessed using random-effects models. A funnel plot and Egger's test were used to determine publication bias. Furthermore, subgroup analysis and dose-response analysis were performed. All analyses were conducted using R (version 4.1.3).
resultsTwenty-four eligible studies involving 1068158 participants were included in this review. The meta-analysis showed that compared to a low intake, a higher intake of citrus, apples, watermelon, and kiwi reduced the risk of CRC by 9% [OR (95%CI) = 0.91 (0.85-0.97)], 25% [OR (95%CI) = 0.75 (0.66-0.85)], 26% [OR (95%CI) = 0.74 (0.58-0.94)], 13% [OR (95%CI) = 0.87 (0.78-0.96)], respectively. No significant association was observed between the intake of other types of fruit and the risk of CRC. In the dose-response analysis, a nonlinear association was found [R (95%CI) = -0.0031 (-0.0047 to -0.0014)] between citrus intake and CRC risk (
conclusionWe found that a higher intake of citrus, apples, watermelon, and kiwi was negatively associated with the risk of CRC, while the intake of other types of fruits were not significantly associated with CRC. Citrus intake showed a non-linear dose-response relationship with the risk of CRC. This meta-analysis provides further evidence that a higher intake of specific types of fruit is effective in preventing the occurrence of CRC.
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