Evidence map›Paper›PMID 37212947›Full record

ArticleMedical oncology (Northwood, London, England)2023

Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC).

Nikhil Chandnani, Vedika Shrirang Choudhari, Rajat Talukdar, Sudeshna Rakshit, Geetha Shanmugam, Shiuli Guchait, Ishika Gupta, Melvin George, Koustav Sarkar

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nikhil Chandnani *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0003-3118-161X
Vedika Shrirang Choudhari *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-9021-9553
Rajat Talukdar *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-5622-7592
Sudeshna Rakshit *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-7496-3155
Geetha Shanmugam *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0003-3035-6190
Shiuli Guchait *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-9521-0072
Ishika Gupta *Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-4010-1389
Melvin GeorgeDepartment of Clinical Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, 603203, Tamil Nadu, India.ORCID http://orcid.org/0000-0001-7101-8513
Koustav SarkarDepartment of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India. koustavsarkar@gmail.com.ORCID http://orcid.org/0000-0002-0696-6688
SRM Institute of Science and Technology · IN

Funding

Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Govt. of India ECR/2016/000965
6 · The paper itself

Abstract

Non-Small Cell Lung Cancer (NSCLC) is the leading cause of death in all countries alike. In the current study, we have found out that Histone H3Lys4trimethylation is abnormal on YY1 in CD4

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCell DifferentiationEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticHistonesHumansLeukocytes, MononuclearTranscription FactorsYin-YangYY1 Transcription FactorEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanHistonesTranscription FactorsYY1 protein, humanYY1 Transcription FactorEZH2NSCLCT cell differentiationTranscription factorsYY1

Identifiers

PMID37212947
OpenAlexW4377220541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.