Evidence map›Paper›PMID 37212931›Full record

Observational studySurgery today2023

An observational study of the impact of immediate breast reconstruction on perioperative inflammatory cytokines.

Yuko Mukai, Naruto Taira, Yohei Kitaguchi, Ryoko Nakagiri, Miho Saiga, Mariko Kochi, Takayuki Iwamoto, Tadahiko Shien, Hiroyoshi Doihara, Yoshihiro Kimata

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Surgery today, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuko MukaiDepartment of Plastic and Reconstructive Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Kita-ku, Okayama Prefecture, Japan. pkyn874i@s.okayama-u.ac.jp.ORCID http://orcid.org/0000-0002-5024-3372
Naruto TairaDepartment of Breast and Thyroid Surgery, Kawasaki Medical School Hospital, Kurashiki-City, Okayama Prefecture, Japan.
Yohei KitaguchiDepartment of Plastic and Reconstructive Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Ryoko NakagiriDepartment of Plastic and Reconstructive Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Miho SaigaDepartment of Plastic and Reconstructive Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Mariko KochiDepartment of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime Prefecture, Japan.
Takayuki IwamotoDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Tadahiko ShienDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Hiroyoshi DoiharaDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Kita-ku, Okayama Prefecture, Japan.
Yoshihiro KimataDepartment of Plastic and Reconstructive Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Kita-ku, Okayama Prefecture, Japan.
Okayama University Hospital · JPOkayama University · JPKawasaki Medical School · JP

Funding

Japan Society for the Promotion of Science 22K10526Japan Society for the Promotion of Science JP 17K17017
6 · The paper itself

Abstract

purposePerioperative inflammatory cytokines may be related to cancer proliferation, although few studies have investigated this issue in patients undergoing breast reconstruction surgery.

methodsWe conducted a prospective study of patients scheduled for mastectomy only, mastectomy plus deep inferior epigastric perforator flap reconstruction (DIEP), or mastectomy plus tissue expander reconstruction (TE), with or without axial dissection (Ax), for primary breast cancer. Blood samples were collected for analysis of serum IL-6 and VEGF preoperatively, then within 24 h postoperatively (POD 1), and 4-6 days postoperatively (POD 4-6). We investigated the difference in serum cytokine levels over time for each surgical procedure and the difference in serum cytokine levels among the procedures at the three measurement time points.

resultsThere were 120 patients included in the final analysis. Serum IL-6 was significantly higher than the preoperative level on POD 1 in patients who underwent mastectomy only, DIEP, or TE and Ax (+), with higher values persisting on POD 4-6 except in those who underwent DIEP. IL-6 was significantly higher after DIEP than after mastectomy only on POD 1, but no differences were observed at POD 4-6. VEGF did not differ significantly among the surgical procedures at any time.

conclusionsThe increase in IL-6 was short term and immediate breast reconstruction is considered a safe procedure.

Indexed as

Breast NeoplasmsMammaplastyPerforator FlapFemaleHumansInterleukin-6MastectomyProspective StudiesRetrospective StudiesVascular Endothelial Growth Factor AInterleukin-6Vascular Endothelial Growth Factor ABreast reconstructionInflammatory cytokinesInterleukin-6Vascular endothelial growth factor

Identifiers

PMID37212931
OpenAlexW4377220770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.