Evidence map›Paper›PMID 37212693›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2023

Generation and Repair of Postreplication Gaps in Escherichia coli.

Michael M Cox, Myron F Goodman, James L Keck, Antoine van Oijen, Susan T Lovett, Andrew Robinson

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RecBCD-dependent post-UV replication restart inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. The Role of the RecFOR Complex in Genome Stability.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Identification ofJournal of bacteriology · 2023
    Article
  20. Molecular insights into the prototypical single-stranded DNA-binding protein fromCritical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael M CoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3606-5722
Myron F GoodmanDepartment of Biological Sciences, University of Southern California, University Park, Los Angeles, California, USA.
James L KeckDepartment of Biological Chemistry, University of Wisconsin-Madison School of Medicine, Madison, Wisconsin, USA.ORCID 0000-0002-5961-0220
Antoine van OijenMolecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia.
Susan T LovettDepartment of Biology, Brandeis University, Waltham, Massachusetts, USA.ORCID 0000-0003-2792-1857
Andrew RobinsonMolecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia.

Funding

Replication Fork RepairR01GM051753 · NIGMS · BRANDEIS UNIVERSITY · PI LOVETT, SUSAN THOMAS · 1994 to 2025
$10.7M
Creation and Repair of Postreplicative DNA GapsRM1GM130450 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Michael M. Cox, MYRON GOODMAN · 2019 to 2026
$10.4M
Hypermutation in Bacteria and HumansR35ES028343 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODMAN, MYRON · 2017 to 2024
$4.3M
NIEHS NIH HHS R35 ES028343NIGMS NIH HHS R01 GM051753NIGMS NIH HHS RM1 GM130450
6 · The paper itself

Abstract

When replication forks encounter template lesions, one result is lesion skipping, where the stalled DNA polymerase transiently stalls, disengages, and then reinitiates downstream to leave the lesion behind in a postreplication gap. Despite considerable attention in the 6 decades since postreplication gaps were discovered, the mechanisms by which postreplication gaps are generated and repaired remain highly enigmatic. This review focuses on postreplication gap generation and repair in the bacterium Escherichia coli. New information to address the frequency and mechanism of gap generation and new mechanisms for their resolution are described. There are a few instances where the formation of postreplication gaps appears to be programmed into particular genomic locations, where they are triggered by novel genomic elements.

Indexed as

Escherichia coliEscherichia coli ProteinsBacterial ProteinsDNA, BacterialDNA-Directed DNA PolymeraseDNA RepairDNA ReplicationBacterial ProteinsDNA, BacterialDNA-Directed DNA PolymeraseEscherichia coli ProteinsDNA recombinationDNA repairmutagenesispostreplication gapRecARecFRecGRecORecRtranslesion DNA synthesis

Identifiers

PMID37212693
PMCPMC10304936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.