Evidence map›Paper›PMID 37212679›Full record

ArticleJournal of bacteriology2023

Paradoxical Activation of a Type VI Secretion System Phospholipase Effector by Its Cognate Immunity Protein.

Steven J Jensen, Zachary C Ruhe, August F Williams, Dinh Q Nhan, Fernando Garza-Sánchez, David A Low, Christopher S Hayes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Steven J Jensen *Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Zachary C Ruhe *Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
August F WilliamsDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Dinh Q NhanDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Fernando Garza-SánchezDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
David A LowDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Christopher S HayesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.ORCID 0000-0002-2216-6445
University of California, Santa Barbara · US

Funding

Molecular Mechanisms of anti-bacterial contact-dependent growth inhibition (CDI)R01GM117930 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2016 to 2023
$3.0M
NIGMS NIH HHS R01 GM117930
6 · The paper itself

Abstract

Type VI secretion systems (T6SSs) deliver cytotoxic effector proteins into target bacteria and eukaryotic host cells. Antibacterial effectors are invariably encoded with cognate immunity proteins that protect the producing cell from self-intoxication. Here, we identify transposon insertions that disrupt the

Indexed as

Type VI Secretion SystemsBacterial ProteinsLipasePhospholipasesProtein Sorting SignalsBacterial ProteinsLipasePhospholipasesProtein Sorting SignalsType VI Secretion Systemscontact-dependent growth inhibitionkin discriminationself/nonself recognitiontoxin immunity proteins

Identifiers

PMID37212679
PMCPMC10294671
OpenAlexW4377220450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.