Evidence map›Paper›PMID 37212596›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.

Ryan C Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C Altman, William A Altemeier, Charles W Frevert, Jason S Debley, Adrian M Piliponsky, Steven F Ziegler and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. MicroRNA clustering in pediatric asthma reveals differential corticosteroid responsiveness.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Eosinophil-Epithelial Cell Interactions in Asthma.International archives of allergy and immunology · 2024
    Review
  16. Article
  17. The ABCs and DEGs (Differentially Expressed Genes) of Airway Hyperresponsiveness.American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ryan C MurphyDivision of Pulmonary, Critical Care and Sleep.ORCID 0000-0003-0094-0003
Ying LaiDivision of Pulmonary, Critical Care and Sleep.
Matthew LiuDivision of Pulmonary, Critical Care and Sleep.
Taha Al-ShaikhlyDivision of Allergy and Infectious Diseases, Department of Medicine.
Matthew C AltmanDivision of Allergy and Infectious Diseases, Department of Medicine.ORCID 0000-0002-1784-8505
William A AltemeierDivision of Pulmonary, Critical Care and Sleep.
Charles W FrevertDepartment of Comparative Medicine.
Jason S DebleyDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington.
Adrian M PiliponskyCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington.
Steven F ZieglerImmunology Program, Benaroya Research Institute, Seattle, Washington.
Sina A GharibDivision of Pulmonary, Critical Care and Sleep.
Teal S HallstrandDivision of Pulmonary, Critical Care and Sleep.ORCID 0000-0002-5059-6872
Pulmonary and Critical Care Associates · USBenaroya Research InstituteSeattle Children's Hospital · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Regulation of the Innate Immune Response by the Epithelium in AsthmaU19AI125378 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2016 to 2020
$9.2M
The Bioinformatics and Data Management Core (BDMC)U19AI175089 · NIAID · UNIVERSITY OF WASHINGTON · PI JASON S DEBLEY, Teal S Hallstrand · 2023 to 2026
$7.8M
Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodelingR01AI163160 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JASON S DEBLEY · 2022 to 2026
$4.3M
Regulation of Allergen-Induced Airway Pathophysiology by VersicanR01AI130280 · NIAID · UNIVERSITY OF WASHINGTON · PI FREVERT, CHARLES WAYNE, HALLSTRAND, TEAL S · 2019 to 2023
$3.8M
Origin and Function of Intra-epithelial Mast Cells in AsthmaR01HL153979 · NHLBI · UNIVERSITY OF WASHINGTON · PI HALLSTRAND, TEAL S · 2021 to 2024
$2.9M
Immunopathology of Indirect Airway Hyperresponsiveness in AsthmaK24AI130263 · NIAID · UNIVERSITY OF WASHINGTON · PI Teal S Hallstrand · 2017 to 2026
$1.3M
Impact of Heterogeneous Airway Epithelial ACE2 Expression and Interferon Responses on SARS-CoV2 Infectivity and ReplicationK24AI150991 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI DEBLEY, JASON S · 2020 to 2024
$1.2M
Function of the IL-18-IL-18R1-IFN-T2 Cytokine Eosinophil Axis in AsthmaF32HL159889 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURPHY, RYAN · 2021 to 2021
$77k
NHLBI NIH HHS F32 HL159889NHLBI NIH HHS R01 HL153979NIAID NIH HHS K24 AI130263NIAID NIH HHS K24 AI150991NIAID NIH HHS R01 AI130280NIAID NIH HHS R01 AI163160NIAID NIH HHS U19 AI125378NIAID NIH HHS U19 AI175089NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaRespiratory HypersensitivityEpithelial CellsHumansImmunity, InnateInflammationInterleukin-18Interleukin-33Interleukin-18Interleukin-33airway epitheliumairway hyperresponsivenessasthmaeosinophilmast cell

Identifiers

PMID37212596
PMCPMC10273121
OpenAlexW4377220037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.