Evidence map›Paper›PMID 37212546›Full record

ArticleAmerican journal of physiology. Cell physiology2023

Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals.

Michaeljohn Kalakoutis, Ross D Pollock, Norman R Lazarus, R Andrew Atkinson, Marc George, Onur Berber, Roger C Woledge, Julien Ochala, Stephen D R Harridge

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Michaeljohn KalakoutisCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0003-0278-7831
Ross D PollockCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Norman R LazarusCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0002-3519-5034
R Andrew AtkinsonRandall Centre for Cell and Molecular Biophysics, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0002-3645-9492
Marc GeorgeGuy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Onur BerberRoyal Free London NHS Foundation Trust, London, United Kingdom.
Roger C WoledgeCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Julien OchalaCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0002-6358-2920
Stephen D R HarridgeCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0002-8203-0769
King's College London · GBCentre National de la Recherche Scientifique · FRGuy's and St Thomas' NHS Foundation Trust · GBRoyal Free London NHS Foundation Trust · GBUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific force (SF) has been shown to be reduced in some but not all studies of human aging using chemically skinned single muscle fibers. This may be due, in part, not only to the health status/physical activity levels of different older cohorts, but also from methodological differences in studying skinned fibers. The aim of the present study was to compare SF in fibers from older hip fracture patients (HFP), healthy master cyclists (MC), and healthy nontrained young adults (YA) using two different activating solutions. Quadriceps muscle samples and 316 fibers were obtained from HFPs (74.6 ± 4 years,

Indexed as

Muscle ContractionMuscle Fibers, SkeletalAgedAgingHumansMuscle, SkeletalMyosin Heavy ChainsQuadriceps MuscleYoung AdultMyosin Heavy Chainsagingmuscle contractionmyosin heavy chainsingle muscle fiberspecific force

Identifiers

PMID37212546
PMCPMC10312328
OpenAlexW4377220990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.