ArticleeLife2023
Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Deep brain stimulation of the hypothalamic region: a systematic review.Acta neurochirurgica · 2025Pooled it
- Effectiveness of deep brain stimulation on refractory aggression in pediatric patients with autism and severe intellectual disability: meta-analytic review.BMC pediatrics · 2024Pooled it
- Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders.Translational psychiatry · 2024Pooled it
- Linking Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: A Randomized Trial.Movement disorders : official journal of the Movement Disorder Society · 2024Trial
- Subregional hypothalamic volumes associate with childhood conduct problems in healthy adults.Brain imaging and behavior · 2026Article
- From lesion to circuit modulation: A narrative review of psychosurgery in refractory obsessive-compulsive disorder, treatment-resistant depression, and pathological aggression.Surgical neurology international · 2026Review
- Three-Dimensional Point-Cloud Learning for Patient-Specific Deep Brain Stimulation Motor Response Prediction in Parkinson Disease.BME frontiers · 2026Article
- Chemoarchitectural studies of the rat hypothalamus and zona incerta.bioRxiv : the preprint server for biology · 2025Article
- Bilateral Focused Ultrasound Thalamotomy for Essential Tremor: Clinical Outcomes Compared to Bilateral Deep Brain Stimulation and Probabilistic Lesion Mapping.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Mapping Lesion-Related Human Aggression to a Common Brain Network.Biological psychiatry · 2025Article
- Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The dark sides of the brain: A systematic review and meta-analysis of functional neuroimaging studies on trait aggressionAggression and violent behavior · 2025Article
- Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour.International journal of molecular sciences · 2025Review
- A large normative connectome for exploring the tractographic correlates of focal brain interventions.Scientific data · 2024Article
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 6 countries.
Funding
Abstract
Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating volume of activated tissue modeling, probabilistic mapping, normative connectomics, and atlas-derived transcriptomics. Ninety-one percent of the patients responded positively to treatment, with a more striking improvement recorded in the pediatric population. Probabilistic mapping revealed an optimized surgical target within the posterior-inferior-lateral region of the posterior hypothalamic area. Normative connectomic analyses identified fiber tracts and functionally connected with brain areas associated with sensorimotor function, emotional regulation, and monoamine production. Functional connectivity between the target, periaqueductal gray and key limbic areas - together with patient age - were highly predictive of treatment outcome. Transcriptomic analysis showed that genes involved in mechanisms of aggressive behavior, neuronal communication, plasticity and neuroinflammation might underlie this functional network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.