Evidence map›Paper›PMID 37212439›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2023

Long-term maternal mortality risk following spontaneous preterm birth: A retrospective cohort study.

Lauren H Theilen, Ibrahim Hammad, Huong Meeks, Alison Fraser, Tracy A Manuck, Michael W Varner, Ken R Smith

Open access · bronzeAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lauren H TheilenDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.ORCID 0000-0002-5662-6040
Ibrahim HammadDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Huong MeeksHuntsman Cancer Institute, Utah Population Database, Salt Lake City, Utah, USA.ORCID 0000-0001-8712-4679
Alison FraserHuntsman Cancer Institute, Utah Population Database, Salt Lake City, Utah, USA.
Tracy A ManuckDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Michael W VarnerDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
Ken R SmithHuntsman Cancer Institute, Utah Population Database, Salt Lake City, Utah, USA.
Huntsman Cancer Institute · USIntermountain Healthcare · USUniversity of North Carolina at Chapel Hill · US

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
The Utah Study of Fertility, Longevity and AgingR01AG022095 · NIA · UNIVERSITY OF UTAH · PI SMITH, KEN R · 2003 to 2015
$9.4M
The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black WomenR01MD011609 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANUCK, TRACY A. · 2017 to 2021
$3.8M
Patient-oriented research and mentoring in preterm birth toxicogenomicsK24ES031131 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TRACY A. MANUCK · 2020 to 2026
$1.0M
Optimizing Cardiovascular Preventive Care for Women following Hypertensive Disorders of Pregnancy.K23HL159316 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Lauren Theilen · 2022 to 2026
$885k
NCATS NIH HHS UM1 TR004409NHLBI NIH HHS K23 HL159316NHLBI NIH HHS K23HL159316NIA NIH HHS R01 AG022095NIA NIH HHS R01AG022095NIEHS NIH HHS K24 ES031131NIEHS NIH HHS K24ES031131NIMHD NIH HHS R01 MD011609NIMHD NIH HHS R01MD011609
6 · The paper itself

Abstract

objectiveTo determine whether women with spontaneous preterm birth (PTB) have increased risks for long-term mortality.

designRetrospective cohort.

settingBirths in Utah between 1939 and 1977. POPULATION: We included women with a singleton live birth ≥20 weeks who survived at least 1 year following delivery. We excluded those who had never lived in Utah, had improbable birthweight/gestational age combinations, underwent induction (except for preterm membrane rupture) or had another diagnosis likely to cause PTB.

methodsExposed women had ≥1 spontaneous PTB between 20

main outcome measuresOverall and cause-specific mortality risks were compared using Cox regression.

resultsWe included 29 048 exposed and 57 992 matched unexposed women. There were 3551 deaths among exposed (12.2%) and 6013 deaths among unexposed women (10.4%). Spontaneous PTB was associated with all-cause mortality (adjusted hazard ratio [aHR] 1.26, 95% confidence interval [CI] 1.21-1.31), death from neoplasms (aHR 1.10, 95% CI 1.02-1.18), circulatory disease (aHR 1.35, 95% CI 1.25-1.46), respiratory disease (aHR 1.73, 95% CI 1.46-2.06), digestive disease (aHR 1.33, 95% CI 1.12-1.58), genito-urinary disease (aHR 1.60, 95% CI 1.15-2.23) and external causes (aHR 1.39, 95% CI 1.22-1.58).

conclusionsSpontaneous PTB is associated with modestly increased risks for all-cause and some cause-specific mortality.

Indexed as

Premature BirthFemaleHumansInfantInfant, NewbornMaternal AgeMaternal MortalityPregnancyPregnancy, MultipleRetrospective StudiesRisk Factorsfollow-up studieslifecoursepremature birthretrospective studieswomen's health

Identifiers

PMID37212439
PMCPMC10592573
OpenAlexW4377221361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.