Evidence map›Paper›PMID 37212184›Full record

ArticleJournal of cachexia, sarcopenia and muscle2023

Low muscle mass, malnutrition, sarcopenia, and associations with survival in adults with cancer in the UK Biobank cohort.

Nicole Kiss, Carla M Prado, Robin M Daly, Linda Denehy, Lara Edbrooke, Brenton J Baguley, Steve F Fraser, Abbas Khosravi, Gavin Abbott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  15. Meeting physical activity guidelines in conjunction with higher protein intake: associations with appendicular lean soft tissue index in middle aged adults with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nicole KissInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.ORCID 0000-0002-6476-9834
Carla M PradoDepartment of Agricultural, Food and Nutrition Science, University of Alberta, Edmonton, Canada.
Robin M DalyInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.
Linda DenehyDepartment of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, Australia.
Lara EdbrookeDepartment of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, Australia.
Brenton J BaguleyInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.
Steve F FraserInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.
Abbas KhosraviInstitute for Intelligent Systems Research and Innovation, Deakin University, Geelong, Australia.
Gavin AbbottInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.
Deakin University · AUThe University of Melbourne · AUUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow muscle mass (MM) is a common component of cancer-related malnutrition and sarcopenia, conditions that are all independently associated with an increased risk of mortality. This study aimed to (1) compare the prevalence of low MM, malnutrition, and sarcopenia and their association with survival in adults with cancer from the UK Biobank and (2) explore the influence of different allometric scaling (height [m

methodsParticipants in the UK Biobank with a cancer diagnosis within 2 years of the baseline assessment were identified. Low MM was estimated by appendicular lean soft tissue (ALST) from bioelectrical impedance analysis derived fat-free mass. Malnutrition was determined using the Global Leadership in Malnutrition criteria. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People criteria (version 2). All-cause mortality was determined from linked national mortality records. Cox-proportional hazards models were fitted to estimate the effect of low MM, malnutrition, and sarcopenia on all-cause mortality.

resultsIn total, 4122 adults with cancer (59.8 ± 7.1 years; 49.2% male) were included. Prevalence of low MM (8.0% vs. 1.7%), malnutrition (11.2% vs. 6.2%), and sarcopenia (1.4% vs. 0.2%) was higher when MM was adjusted using ALST/BMI compared with ALST/height

conclusionsIn adults with cancer, malnutrition was more common than low MM or sarcopenia, although all conditions were associated with a higher mortality risk, regardless of the method of adjusting for MM. In contrast, adjustment of low MM for BMI identified more cases of low MM, malnutrition, and sarcopenia overall and in participants with obesity compared with height adjustment, suggesting it is the preferred adjustment.

Indexed as

MalnutritionNeoplasmsSarcopeniaAdultAgedBiological Specimen BanksFemaleHumansMaleMiddle AgedMusclesObesityUnited KingdomCancerLow muscle massMalnutritionMortalitySarcopeniaUK Biobank

Identifiers

PMID37212184
PMCPMC10401543
OpenAlexW4377220341

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.