Evidence map›Paper›PMID 37212153›Full record

ArticleJournal of applied biomedicine2023

The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice.

Shanshan Qi, Beibei Lin, Sanqiao Wu, Hao Hao, Hongxin Zheng, Xiang Liu, Xiaoying Zhang, Lijuan Yue, Chen Chen

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Journal of applied biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shanshan QiShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Beibei LinShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Sanqiao WuShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Hao HaoShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Hongxin ZhengShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Xiang LiuShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Xiaoying ZhangShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Lijuan Yue
Chen ChenShaanxi University of Technology, College of Biological Science and Engineering, Hanzhong, Shaanxi Province, 723000, China.
Shaanxi University of Technology · CNHanzhong Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research demonstrated the protective effect and possible mechanism of the Sophora viciifolia extract (SVE) against acetaminophen-induced liver injury in mice. The levels of ALT and AST in the serum and antioxidant enzyme activity in the liver were measured. We used immunohistochemistry to detect CYP2E1, Nrf2, and Keap1 protein expression in the liver. The mRNA expression in the liver of TNF-α, NF-κB, and IL-6, Nrf2 and its downstream genes HO-1 and GCLC were measured by qRT-PCR. We found that SVE could decrease the ALT and AST levels, promote the activities of SOD, CAT, GSH-Px, and GSH, and ameliorate pathological liver lesions. SVE could down-regulate the mRNA expression of inflammatory factors and up-regulate Nrf2, HO-1 and GCLC. SVE reduced the protein expression of the CYP2E1 and increased the Nrf2 and Keap1. SVE has been shown to have a protective effect against APAP-induced liver injury, possibly through activation of the Keap1-Nrf2 pathway.

Indexed as

AcetaminophenChemical and Drug Induced Liver Injury, ChronicAnimalsAntioxidantsCytochrome P-450 CYP2E1FruitKelch-Like ECH-Associated Protein 1MiceNF-E2-Related Factor 2RNA, MessengerAcetaminophenAntioxidantsCytochrome P-450 CYP2E1Kelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2RNA, MessengerAcetaminophen (APAP)Keap1-Nrf2Liver injurySophora viciifolia fruit extract

Identifiers

PMID37212153
OpenAlexW4377107558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.