ArticleStroke2023
Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study.
Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.Journal of the American Heart Association · 2026Article
- Associations between female sex-specific risk factors and cardiometabolic multimorbidity: evidence from the UK Biobank cohort study.BMC public health · 2026Article
- Adverse Pregnancy Outcomes and Cognitive Change in Older Women.Journal of women's health (2002) · 2026Article
- Adverse pregnancy outcomes and long-term risk of stroke: a Swedish nationwide co-sibling study.European heart journal · 2025Article
- History of pre-eclampsia negatively impacts stroke severity postpartum in rats.Neuroprotection (Chichester, England) · 2025Article
- Multimorbidity Patterns and In-Hospital Outcomes in Chinese Young Women (Aged <55 Years) Presenting with ST-Segment-Elevation Myocardial Infarction.Journal of the American Heart Association · 2025Article
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.Circulation research · 2025Review
- Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care.Circulation · 2025Review
- Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Identification of the Shared Gene Signatures and Pathways Between Polycystic Ovary Syndrome and Endometrial Cancer Using Bioinformatics and Mendelian Randomization Analyses.International journal of women's health · 2025Article
- Dietary Inflammatory Index Is Differentially Associated With Cardiometabolic Health After Pregnancy on the Basis of Adverse Pregnancy Outcome Exposure.Journal of the American Heart Association · 2024Article
- Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Review
- Impact of adverse pregnancy outcomes on brain vascular health and cognition.Research and practice in thrombosis and haemostasis · 2024Article
- Hypertensive disorders of pregnancy and stroke: a univariate and multivariate Mendelian randomization study.Frontiers in endocrinology · 2024Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAdverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized that APO are associated with younger age at first stroke, with a stronger relationship in those with >1 pregnancy with APO.
methodsWe analyzed longitudinal Finnish nationwide health registry data from the FinnGen Study. We included women who gave birth after 1969 when the hospital discharge registry was established. We defined APO as a pregnancy affected by gestational hypertension, preeclampsia, eclampsia, preterm birth, small for gestational age infant, or placental abruption. We defined stroke as first hospital admission for ischemic stroke or nontraumatic intracerebral or subarachnoid hemorrhage, excluding stroke during pregnancy or within 1 year postpartum. We used Kaplan-Meier survival curves and multivariable-adjusted Cox and generalized linear models to assess the relationship between APO and future stroke.
resultsWe included 144 306 women with a total of 316 789 births in the analysis sample, of whom 17.9% had at least 1 pregnancy with an APO and 2.9% experienced an APO in ≥2 pregnancies. Women with APO had more comorbidities including obesity, hypertension, heart disease, and migraine. Median age at first stroke was 58.3 years in those with no APO, 54.8 years in those with 1 APO, and 51.6 years in those with recurrent APO. In models adjusted for sociodemographic characteristics and stroke risk factors, risk of stroke was greater in women with 1 APO (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.4]) and recurrent APO (adjusted hazard ratio, 1.4 [95% CI, 1.2-1.7]) compared with those with no APO. Women with recurrent APO had more than twice the stroke risk before age 45 (adjusted odds ratio, 2.1 [95% CI, 1.5-3.1]) compared with those without APO.
conclusionsWomen who experience APO have earlier onset of cerebrovascular disease, with the earliest onset in those with more than 1 affected pregnancy.
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