Evidence map›Paper›PMID 37212115›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Area-Level Infant Mortality Exposure in Early Life and Alzheimer's Disease Mortality: Examining Variation Based on Age, Sex, and Place of Birth.

Michael Topping, Jinho Kim, Jason Fletcher

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael ToppingDepartment of Sociology, University of Wisconsin-Madison, Madison, WI, USA.
Jinho KimCenter for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
Jason FletcherCenter for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.

Funding

Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
The Importance of Place in Determining Health and Mortality at Older AgesR01AG060109 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FLETCHER, JASON MICHAEL, PALLONI, ALBERTO B. · 2018 to 2022
$2.2M
The Importance of Place of Birth in Determining Old Age Cognitive HealthRF1AG062765 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FLETCHER, JASON MICHAEL, PALLONI, ALBERTO B. · 2019 to 2019
$1.6M
NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG060109NIA NIH HHS RF1 AG062765
6 · The paper itself

Abstract

backgroundGrowing evidence suggests that critical periods in early life may contribute to one's risk of Alzheimer's disease and related dementias (ADRD) in later life. In this paper we explore the role that exposure to infant mortality plays in later life ADRD.

objectiveTo determine if exposure to early life infant mortality is associated with later mortality from ADRD. Also, we explore how these associations differ by sex and age group, along with the role of state of birth and competing risks of death.

methodsWe use a sample of over 400,000 individuals aged 50 and above with the NIH-AARP Diet and Health Study with mortality follow-up, allowing us to examine how early life infant mortality rates along with other risk factors play in one's individual mortality risk.

resultsWe show that infant mortality rates are associated with death from ADRD among those under 65 years of age, but not those over 65 at baseline interview. Moreover, when factoring in competing risks of death, the associations are relatively unchanged.

conclusionThese results suggest that those exposed to worse adverse conditions during critical periods increase their likelihood of death from ADRD earlier than average, due to that exposure increasing their susceptibility to develop illness later on in life.

Indexed as

Alzheimer DiseaseInfant MortalityAgedFemaleHumansInfant, NewbornMaleMiddle AgedRisk FactorsAlzheimer’s diseaseearly lifeinfant mortalitymortalityplace of birth

Identifiers

PMID37212115
PMCPMC10398565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.