ArticleJournal of Parkinson's disease2023
Dopaminergic Dysfunction Is More Symmetric in Dementia with Lewy Bodies Compared to Parkinson's Disease.
Article in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Brain-first and body-first subtypes of Lewy body disease.Nature reviews. Neurology · 2026Review
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
- Lipidomic perspectives on the role of lactosylceramides in inflammation and disease: A narrative review.Expert reviews in molecular medicine · 2026Review
- Is motor asymmetry a predictor of non-motor outcomes in Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- From Neuroadaptation to Neuroprogression: Rethinking Chronic Cocaine Exposure Through a Model of Cocaine-Related Cerebropathy.Journal of clinical medicine · 2026Article
- A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism usingNeuroImage. Clinical · 2026Article
- Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis.NPJ Parkinson's disease · 2025Article
- Inter-relationship of the age of onset to the concept of brain-first versus body-first Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases.Schizophrenia bulletin · 2025Review
- Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology.Molecular neurodegeneration · 2025Review
- [PCN reports : psychiatry and clinical neurosciences · 2025Article
- Non-motor asymmetry and dopamine degeneration in Parkinson's disease.Brain communications · 2025Article
- Exploring the relation between REM sleep behavior disorder onset and striatal dopaminergic dysfunction in Parkinson's Disease.Journal of neurology · 2024Article
- Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion.European journal of neurology · 2024Article
- Investigating the aspect of asymmetry in brain-first versus body-first Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.Journal of Alzheimer's disease : JAD · 2024Article
- Approaches to Early Parkinson's Disease Subtyping.Journal of Parkinson's disease · 2024Review
- Parkinson's Disease and Dementia with Lewy Bodies: One and the Same.Journal of Parkinson's disease · 2024Review
- The Body, the Brain, the Environment, and Parkinson's Disease.Journal of Parkinson's disease · 2024Review
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe α-syn Origin site and Connectome model (SOC) proposes that α-synucleinopathies can be divided into two categories: the asymmetrical brain-first, and more symmetrical body-first Lewy body disease. We have hypothesized that most patients with dementia with Lewy bodies (DLB) belong to the body-first subtype, whereas patients with Parkinson's disease (PD) more often belong to the brain-first subtype.
objectiveTo compare asymmetry of striatal dopaminergic dysfunction in DLB and PD patients using [18F]-FE-PE2I positron emission tomography (PET).
methodsWe analyzed [18F]-FE-PE2I PET data from 29 DLB patients and 76 PD patients who were identified retrospectively during a 5-year period at Dept. of Neurology, Aarhus University Hospital. Additionally, imaging data from 34 healthy controls was used for age-correction and visual comparison.
resultsPD patients showed significantly more asymmetry in specific binding ratios between the most and least affected putamen (p < 0.0001) and caudate (p = 0.003) compared to DLB patients. PD patients also had more severe degeneration in the putamen compared to the caudate in comparison to DLB patients (p < 0.0001) who had a more universal pattern of striatal degeneration.
conclusionPatients with DLB show significantly more symmetric striatal degeneration on average compared to PD patients. These results support the hypothesis that DLB patients may be more likely to conform to the body-first subtype characterized by a symmetrical spread of pathology, whereas PD patients may be more likely to conform to the brain-first subtype with more lateralized initial propagation of pathology.
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