ArticleJournal of Parkinson's disease2023
Mapping Relevance of Digital Measures to Meaningful Symptoms and Impacts in Early Parkinson's Disease.
Article in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Reciprocity in research: Participant views on return of results in the WATCH-PD qualitative study.Journal of Parkinson's disease · 2026Article
- Digital Motor Outcomes Capture Upper Limb and Mild Stage Impairment in Hereditary Spastic Paraplegia.Neurology and therapy · 2026Article
- Daily-Life, Sensor-Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease.Annals of neurology · 2026Article
- Bridging the global Parkinson's divide: Technology as a structural solution for equitable and brain health-integrated care.Journal of Parkinson's disease · 2026Review
- Domains of Caregiving in Parkinson's Disease: A Framework Developed Through Perspective Mapping.The American journal of hospice & palliative care · 2026Article
- Three years later: tracking bothersome symptoms and impacts for people with early Parkinson's disease.Journal of neurology · 2026Article
- Cognitive Endpoints in Huntington's Disease Trials: A Conceptual Framework for Clinical Meaningfulness.Movement disorders clinical practice · 2026Article
- Neural correlates of Parkinson's improvements after combined digital-levodopa therapy: a pilot study.Brain communications · 2026Article
- Do cognitive tests capture symptoms that matter to people with Huntington's disease?Scientific reports · 2025Article
- Optimizing the MDS-UPDRS Part III for early-stage Parkinson's: early supportive evidence for a limb-related bradykinesia/rigidity sub-score.NPJ Parkinson's disease · 2025Article
- Perspective Mapping: Tutorial for Collecting Quantifiable Qualitative Interview Data.Journal of medical Internet research · 2025Article
- Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem.Journal of medical Internet research · 2025Article
- Digital Health in Parkinson's Disease and Atypical Parkinsonism-New Frontiers in Motor Function and Physical Activity Assessment: Review.Journal of clinical medicine · 2025Review
- Using machine learning to identify Parkinson's disease severity subtypes with multimodal data.Journal of neuroengineering and rehabilitation · 2025Article
- Modernizing the Staging of Parkinson Disease Using Digital Health Technology.Journal of medical Internet research · 2025Article
- Developing digital health technologies for frontotemporal degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Characterizing Hand Function in Parkinson's Disease Patients with a Self-Administered Electronic Manual Dexterity Test.Movement disorders clinical practice · 2025Article
- Longitudinal qualitative assessment of meaningful symptoms and relevance of WATCH-PD digital measures for people with early Parkinson's.Journal of neurology · 2025Article
- Accelerating Parkinson's Disease drug development with federated learning approaches.NPJ Parkinson's disease · 2024Review
- Implementing sensor-based digital health technologies in clinical trials: Key considerations from the eCOA Consortium.Clinical and translational science · 2024Review
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdoption of new digital measures for clinical trials and practice has been hindered by lack of actionable qualitative data demonstrating relevance of these metrics to people with Parkinson's disease.
objectiveThis study evaluated of relevance of WATCH-PD digital measures to monitoring meaningful symptoms and impacts of early Parkinson's disease from the patient perspective.
methodsParticipants with early Parkinson's disease (N = 40) completed surveys and 1:1 online-interviews. Interviews combined: 1) symptom mapping to delineate meaningful symptoms/impacts of disease, 2) cognitive interviewing to assess content validity of digital measures, and 3) mapping of digital measures back to personal symptoms to assess relevance from the patient perspective. Content analysis and descriptive techniques were used to analyze data.
resultsParticipants perceived mapping as deeply engaging, with 39/40 reporting improved ability to communicate important symptoms and relevance of measures. Most measures (9/10) were rated relevant by both cognitive interviewing (70-92.5%) and mapping (80-100%). Two measures related to actively bothersome symptoms for more than 80% of participants (Tremor, Shape rotation). Tasks were generally deemed relevant if they met three participant context criteria: 1) understanding what the task measured, 2) believing it targeted an important symptom of PD (past, present, or future), and 3) believing the task was a good test of that important symptom. Participants did not require that a task relate to active symptoms or "real" life to be relevant.
conclusionDigital measures of tremor and hand dexterity were rated most relevant in early PD. Use of mapping enabled precise quantification of qualitative data for more rigorous evaluation of new measures.
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