Evidence map›Paper›PMID 37212053›Full record

ArticleInternational journal of technology assessment in health care2023

Demonstrating proof of concept for value-based agreements in Europe: two real-world cases.

Elizabeth A Griffiths, Onivefu E Odelade, Joana Gostkorzewicz, Luis Cordero

Abstract read
In one paragraph

Article in International journal of technology assessment in health care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Proof of concept studies in mental health systems research: strategy and steps.International journal of mental health systems · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth A GriffithsAstraZeneca, Cambridge, UK.ORCID https://orcid.org/0000-0002-8800-4430
Onivefu E OdeladeAstraZeneca, Cambridge, UK.
Joana GostkorzewiczAstraZeneca, Madrid, Spain.
Luis CorderoIndependent Consultant, Madrid, Spain.

Funding

AstraZeneca
6 · The paper itself

Abstract

objectivesValue-based agreements (VBAs) link access, reimbursement, or price to the real-world usage and impact of a medicine, thereby enabling patient access while reducing clinical or financial uncertainty for the payer. VBAs have the potential to support improved patient outcomes, given the value-oriented approach to care, and lead to overall savings, while enabling payers to share risk and reduce uncertainty.

methodsThis commentary outlines the key challenges, enablers, and a framework for successful implementation by comparing the experience of two VBAs for AstraZeneca medicines, aiming to increase confidence in their future use.

resultsEngagement by payers, manufacturers, physicians, and provider institutions, and robust data collection systems that are accessible, simple to use, and add little burden to physicians were key to successfully negotiating a VBA that worked for all stakeholders. In both country systems, a legal/policy framework enabled innovative contracting.

conclusionsThese examples demonstrate proof of concept for VBA implementation in different settings, and may inform future VBAs.

Indexed as

Value-Based PurchasingEuropeHumansPharmaceutical PreparationsPharmaceutical Preparationsaccess to medicinesfinancial risk sharingproof of concept studyReimbursement mechanismsvalue-based purchasing

Identifiers

PMID37212053
PMCPMC11574532

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.