Evidence map›Paper›PMID 37211601›Full record

ArticleJournal of nanobiotechnology2023

Multifunctional antibacterial bioactive nanoglass hydrogel for normal and MRSA infected wound repair.

Long Zhang, Wen Niu, Yuyao Lin, Junping Ma, Tongtong Leng, Wei Cheng, Yidan Wang, Min Wang, Jingya Ning, Shuanying Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Long ZhangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. longzhang@xjtu.edu.cn.
Wen NiuFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Yuyao LinDepartment of Plastic, Aesthetic and Maxillofacial Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Junping MaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Tongtong LengFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Wei ChengFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Yidan WangFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Min WangHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710068, China.
Jingya NingDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Shuanying YangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. yangshuanying@xjtu.edu.cn.
Bo LeiFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNXi'an Honghui Hospital · CN

Funding

China Postdoctoral Science Foundation 2021M692578Fundamental Research Funds for the Central Universities xzy012022114
6 · The paper itself

Abstract

Large-scale skin damage brings potential risk to patients, such as imbalance of skin homeostasis, inflammation, fluid loss and bacterial infection. Moreover, multidrug resistant bacteria (MDRB) infection is still a great challenge for skin damage repair. Herein, we developed an injectable self-healing bioactive nanoglass hydrogel (FABA) with robust antibacterial and anti-inflammatory ability for normal and Methicillin-resistant Staphylococcus aureus (MRSA) infected skin wound repair. FABA hydrogel was fabricated facilely by the self-crosslinking of F127-CHO (FA) and alendronate sodium (AL)-decorated Si-Ca-Cu nanoglass (BA). FABA hydrogel could significantly inhibit the growth of Staphylococcus aureus, Escherichia coli and MRSA in vitro, while showing good cytocompatibility and hemocompatibility. In addition, FABA hydrogel could inhibit the expression of proinflammatory factor TNF-α and enhance the expression of anti-inflammatory factor IL-4/ IL-10. Based on its versatility, FABA hydrogel could complete wound closure efficiently (75% at day 3 for normal wound, 70% at day 3 for MRSA wound), which was almost 3 times higher than control wound, which was related with the decrease of inflammatory factor in early wound. This work suggested that FABA hydrogel could be a promising dressing for acute and MRSA-infected wound repair.

Indexed as

Methicillin-Resistant Staphylococcus aureusAlendronateAnti-Bacterial AgentsEscherichia coliHumansHydrogelsStaphylococcus aureusAlendronateAnti-Bacterial AgentsHydrogelsAnti-inflammatoryBioactive glassBioactive materialsMultifunctional hydrogelWound repair

Identifiers

PMID37211601
PMCPMC10200057
OpenAlexW4377193310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.