Evidence map›Paper›PMID 37211457›Full record

ReviewZeitschrift fur medizinische Physik2023

Super-resolution ultrasound microvascular imaging: Is it ready for clinical use?

Pengfei Song, Jonathan M Rubin, Matthew R Lowerison

Abstract readReview
In one paragraph

Review in Zeitschrift fur medizinische Physik, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
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  4. Solid Hydrogel Couplants for Skin Superficial Blood Flow Imaging With Super-Resolution Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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  15. Clinical Applications of Advanced Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pengfei SongDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, United States; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, United States; Department of Bioengineering, University of Illinois Urbana-Champaign, United States; Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, United States. Electronic address: songp@illinois.edu.
Jonathan M RubinDepartment of Radiology, University of Michigan, Ann Arbor, United States.
Matthew R LowerisonDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, United States; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, United States.

Funding

Next-Generation Ultrasound Localization MicroscopyR21EB030072 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SONG, PENGFEI · 2020 to 2022
$927k
Early prediction of colorectal liver metastases treatment response with ultrasound microvessel imagingR00CA214523 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SONG, PENGFEI · 2019 to 2021
$684k
Super-resolution imaging of brain microvascular changes in a model of Alzheimer DiseaseR21AG077173 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LLANO, DANIEL A · 2022 to 2022
$422k
NCI NIH HHS R00 CA214523NIA NIH HHS R21 AG077173NIBIB NIH HHS R21 EB030072
6 · The paper itself

Abstract

The field of super-resolution ultrasound microvascular imaging has been rapidly growing over the past decade. By leveraging contrast microbubbles as point targets for localization and tracking, super-resolution ultrasound pinpoints the location of microvessels and measures their blood flow velocity. Super-resolution ultrasound is the first in vivo imaging modality that can image micron-scale vessels at a clinically relevant imaging depth without tissue destruction. These unique capabilities of super-resolution ultrasound provide structural (vessel morphology) and functional (vessel blood flow) assessments of tissue microvasculature on a global and local scale, which opens new doors for many enticing preclinical and clinical applications that benefit from microvascular biomarkers. The goal of this short review is to provide an update on recent advancements in super-resolution ultrasound imaging, with a focus on summarizing existing applications and discussing the prospects of translating super-resolution imaging to clinical practice and research. In this review, we also provide brief introductions of how super-resolution ultrasound works, how does it compare with other imaging modalities, and what are the tradeoffs and limitations for an audience who is not familiar with the technology.

Indexed as

MicrobubblesMicrovesselsUltrasonographyMicrovascular imagingSuper-resolutionUltrasoundUltrasound localization microscopy

Identifiers

PMID37211457
PMCPMC10517403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.