ArticleDevelopmental cognitive neuroscience2023
Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.
Article in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Measuring adversity in the ABCD® Study: systematic review and recommendations for best practices.BMC medical research methodology · 2025Pooled it
- Pooled it
- Effects of adverse childhood experiences on behavior in adolescence: Insights from brain imaging and genetic risk.Developmental cognitive neuroscience · 2026Article
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.Developmental cognitive neuroscience · 2026Article
- Threat, Emotion Dysregulation, and Parenting in a Clinical Sample of Children with Disruptive Behaviour.Child psychiatry and human development · 2026Article
- Timing and tempo of puberty and neurodevelopment following adversity: A registered report.Developmental cognitive neuroscience · 2026Article
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A Bayesian Integrative Mixed Modeling Framework for Analysis of the Multi-Site Adolescent Brain and Cognitive Development Study.Data science in science · 2026Article
- The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Adverse Experiences, Protective Factors, and Obesity in Latinx and Hispanic Youths.JAMA network open · 2025Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.bioRxiv : the preprint server for biology · 2025Article
- Leveraging multivariate approaches to advance the science of early-life adversity.Child abuse & neglect · 2025Review
- Pubertal mediators of early life stress and age on adolescent alcohol initiation: Analysis by sex.Psychoneuroendocrinology · 2025Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Article
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
Early-life adversity has profound consequences for youth neurodevelopment and adjustment; however, experiences of adversity are heterogeneous and interrelated in complex ways that can be difficult to operationalize and organize in developmental research. We sought to characterize the underlying dimensional structure of co-occurring adverse experiences among a subset of youth (ages 9-10) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 7115), a community sample of youth in the United States. We identified 60 environmental and experiential variables that reflect adverse experiences. Exploratory factor analysis identified 10 robust dimensions of early-life adversity co-occurrence, corresponding to conceptual domains such as caregiver substance use and biological caregiver separation, caregiver psychopathology, caregiver lack of support, and socioeconomic disadvantage / neighborhood lack of safety. These dimensions demonstrated distinct associations with internalizing problems, externalizing problems, cognitive flexibility, and inhibitory control. Non-metric multidimensional scaling characterized qualitative similarity among the 10 identified dimensions. Results supported a nonlinear three-dimensional structure representing early-life adversity, including continuous gradients of "perspective", "environmental uncertainty", and "acts of omission/commission". Our findings suggest that there are distinct dimensions of early-life adversity co-occurrence in the ABCD sample at baseline, and the resulting dimensions may have unique implications for neurodevelopment and youth behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.