Evidence map›Paper›PMID 37210569›Full record

ArticleArthritis research & therapy2023

Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study.

Douglas R Moellering, Kelley Smith-Johnston, Christian Kelley, Melissa J Sammy, Jason Benedict, Guy Brock, Jillian Johnson, Kedryn K Baskin, Wael N Jarjour, Martha A Belury and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Douglas R MoelleringDepartment of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Kelley Smith-JohnstonDepartment of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Christian KelleyCenter for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Melissa J SammyDepartment of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Jason BenedictDepartment of Biomedical Bioinformatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Guy BrockDepartment of Biomedical Bioinformatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Jillian JohnsonDepartment of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA.
Kedryn K BaskinDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Wael N JarjourDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Martha A BeluryDepartment of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA.
Peter J ReiserDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Prabhakara R NagareddyDepartment of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA.
Beatriz Y HanaokaDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. Beatriz.Hanaoka@osumc.edu.
The Ohio State University · USUniversity of Alabama at Birmingham · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injuryR01HL156856 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Prabhakara Reddy Nagareddy · 2022 to 2026
$2.9M
Skeletal Muscle in Rheumatoid ArthritisK23AR068450 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HANAOKA, BEATRIZ · 2016 to 2022
$929k
NCATS NIH HHS UL1 TR002733NCATS NIH HHS UL1 TR003096NHLBI NIH HHS R01 HL156856NIAMS NIH HHS K23 AR068450NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundInsulin resistance affects a substantial proportion of patients with rheumatoid arthritis (RA). Skeletal muscle mitochondrial dysfunction results in the accumulation of lipid intermediates that interfere with insulin signaling. We therefore sought to determine if lower oxidative phosphorylation and muscle mitochondrial content are associated with insulin resistance in patients with RA.

methodsThis was a cross-sectional prospective study of RA patients. Matsuda index from the glucose tolerance test was used to estimate insulin sensitivity. Mitochondrial content was measured by citrate synthase (CS) activity in snap-frozen muscle samples. Mitochondrial function was measured by using high-resolution respirometry of permeabilized muscle fibers and electron transport chain complex IV enzyme kinetics in isolated mitochondrial subpopulations.

resultsRA participants demonstrated lower insulin sensitivity as measured by the Matsuda index compared to controls [median 3.95 IQR (2.33, 5.64) vs. 7.17 (5.83, 7.75), p = 0.02]. There was lower muscle mitochondrial content among RA vs. controls [median 60 mU/mg IQR (45, 80) vs. 79 mU/mg (65, 97), p = 0.03]. Notably, OxPhos normalized to mitochondrial content was higher among RA vs. controls [mean difference (95% CI) = 0.14 (0.02, 0.26), p = 0.03], indicating a possible compensatory mechanism for lower mitochondrial content or lipid overload. Among RA participants, the activity of muscle CS activity was not correlated with the Matsuda index (ρ =  - 0.05, p = 0.84), but it was positively correlated with self-reported (IPAQ) total MET-minutes/week (ρ = 0.44, p = 0.03) and Actigraph-measured time on physical activity (MET rate) (ρ = 0.47, p = 0.03).

conclusionsMitochondrial content and function were not associated with insulin sensitivity among participants with RA. However, our study demonstrates a significant association between muscle mitochondrial content and physical activity level, highlighting the potential for future exercise interventions that enhance mitochondrial efficiency in RA patients.

Indexed as

Arthritis, RheumatoidInsulin ResistanceCase-Control StudiesCross-Sectional StudiesHumansLipidsMitochondriaMitochondria, MuscleMuscle, SkeletalProspective StudiesLipidsMitochondriaRheumatoid arthritisSkeletal muscle

Identifiers

PMID37210569
PMCPMC10199606
OpenAlexW4377137943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.