ArticleBMC research notes2023
Combination therapy: synergism among three plant extracts against selected pathogens.
Article in BMC research notes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Chemical profile and bacterial potential of Psidium cattleyanum leaf extract against multidrug-resistant Staphylococcus aureus.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Probiotic-Plant Bioactive Synergy in Gut Health: Mechanisms, Antimicrobial Activity, and Translational Challenges.Nutrients · 2026Review
- Nanoemulsions of 1,8-cineole, and Eucalyptus globulus and Laurus nobilis essential oils: cytotoxic, antibacterial, and antioxidant activities.BMC complementary medicine and therapies · 2026Article
- Phytotherapeutic Potential of Medicinal Plants for Atopic Dermatitis:Biomolecules & therapeutics · 2026Review
- Silibinin Potentiates Antimicrobial Action and Reduces Staphyloxanthin inPharmaceuticals (Basel, Switzerland) · 2026Article
- Chemical Characteristics and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2026Article
- Phytochemical Analysis of Different Plant Organs of Bauhinia kockiana Korth. and Its Antibacterial Synergistic Interaction.Applied biochemistry and biotechnology · 2026Article
- Formulation andFrontiers in pharmacology · 2026Article
- Octadecyl 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propanoate nanosponges: enhanced antibacterial and antibiofilm activity against multidrug-resistantFrontiers in cellular and infection microbiology · 2026Article
- Evaluating the antifungal efficacy and bioactive metabolites of a traditional polyherbal aqueous formulation BioCC+ against Fusarium graminearum and Fusarium verticillioides.Access microbiology · 2026Article
- Article
- African medicinal plants with anthelmintic properties against selected zoonotic helminths: a scoping review.Helminthologia · 2025Review
- Review
- Phytochemical Characterization and In Vitro Biological Activities ofMolecules (Basel, Switzerland) · 2025Article
- Synergistic Interactions Between Natural Phenolic Compounds and Antibiotics Against Multidrug-ResistantMicroorganisms · 2025Article
- Natural Molecules, Nutraceuticals, and Engineered Nanosystems: A Comprehensive Strategy for CombatingMicroorganisms · 2025Review
- Synergistic Combinations of Native Australian Plants For Skin Inflammation and Wound Healing.Biomedicines · 2025Article
- Evaluating the Analgesic, Hemostatic, and Antimicrobial Potential of a Novel Herbal Formulation for Dental Use.Cureus · 2025Article
- Nutritional and Therapeutic Potential of Longan Fruit By-products for Liver Diseases: Pathway to Functional Foods.Current nutrition reports · 2025Review
- Synergistic Antifungal Effect and In Vivo Toxicity of a Monoterpene Isoespintanol Obtained fromMolecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe synergism among extracts of Senna alata, Ricinus communis, and Lannea barteri, and their anti-infective activities were investigated. The data collected for the antimicrobial activity of the extracts combinations were interpreted to be one of the following categories: synergy; indifferent; additive; or antagonistic. The interpretation was made based on the fractional inhibitory concentration index (FICI) results. FICI of ≤ 0.5 indicates synergism, > 0.5 to 1 indicates additive effects, > 1 to ≤ 4 indifference, and > 4 is considered to be antagonism.
resultsCompared with the data of the individual extracts, the MIC values of the extract-extract combinations against all strains of the tested microorganisms were significantly lower, ranging from 0.97 to 1.17, 0.97 to 4.69, 0.50 to 1.17, 1.17 to 3.12 and 2.34 to 4.69 mg/mL for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Candida albicans respectively. L. bateri aqueous-S. alata ethanol extracts and S. alata aqueous-R. cummunis ethanol extracts combinations showed a synergy effect against all the test microorganisms. The other combinations exhibited at least one additive effect. Neither antagonism nor indifference activity was observed. This study validates the relevance of combining these plants in treating infections by traditional medicine practitioners.
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