Evidence map›Paper›PMID 37210476›Full record

ArticleBMC complementary medicine and therapies2023

Network pharmacology and molecular docking study for biological pathway detection of cytotoxicity of the yellow jasmine flowers.

Seham S El-Hawary, Marzough A Albalawi, Ayat O S Montasser, Shaimaa R Ahmed, Sumera Qasim, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Omnia F Hassan, Abdelfattah A Sadakah and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Seham S El-HawaryDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt.
Marzough A AlbalawiDepartment of Chemistry, Alwajh College, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Ayat O S MontasserNational Organization for Drug Control (NODCAR), Cairo, Egypt.
Shaimaa R AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt.
Sumera QasimDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.
Ali A ShatiKing Khalid University, Faculty of Science, Biology Department, Abha, 9004, Saudi Arabia.
Mohammad Y AlfaifiKing Khalid University, Faculty of Science, Biology Department, Abha, 9004, Saudi Arabia.
Serag Eldin I ElbehairiKing Khalid University, Faculty of Science, Biology Department, Abha, 9004, Saudi Arabia.
Omnia F HassanDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, MSA University, 6th of October City, Egypt.
Abdelfattah A SadakahOral and Maxillofacial Surgery Department, Faculty of Dentistry, Tanta University, Tanta, Egypt.
Fatma A MokhtarDepartment of Pharmacognosy, Faculty of Pharmacy, Al Salam University, Kafr Alzayat, Al Gharbia, Egypt. Fatma.Mokhtar@sue.edu.eg.ORCID http://orcid.org/0000-0002-6909-7440
King Khalid University · SACairo University · EGAl-Azhar University · EGJouf University · SANational Organization for Drug Control and Research · EGOctober University of Modern Sciences and Arts · EGTanta University · EGUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe yellow jasmine flower (Jasminum humile L.) is a fragrant plant belonging to the Oleaceae family with promising phytoconstituents and interesting medicinal uses. The purpose of this study was to characterize the plant metabolome to identify the potential bioactive agents with cytotoxic effects and the underlying mechanism of cytotoxic activity.

methodsFirst, HPLC-PDA-MS/MS was used to identify the potential bioactive compounds in the flowers. Furthermore, we assessed the cytotoxic activity of the flower extract against breast cancer (MCF-7) cell line using MTT assay followed by the cell cycle, DNA-flow cytometry, and Annexin V-FITC analyses alongside the effect on reactive oxygen species (ROS). Finally, Network pharmacology followed by a molecular docking study was performed to predict the pathways involved in anti-breast cancer activity.

resultsHPLC-PDA-MS/MS tentatively identified 33 compounds, mainly secoiridoids. J. humile extract showed a cytotoxic effect on MCF-7 breast cancer cell line with IC

conclusionOur findings suggest that J. humile suppresses breast cancer proliferation and induces cell cycle arrest and apoptosis partly by EGFR signaling pathway, highlighting J. humile as a potential therapeutic candidate against breast cancer.

Indexed as

Antineoplastic AgentsBreast NeoplasmsJasminumErbB ReceptorsFemaleFlowersHumansMolecular Docking SimulationNetwork PharmacologyPlant ExtractsTandem Mass SpectrometryAntineoplastic AgentsErbB ReceptorsPlant ExtractsApoptosisJasminum humileLC/MS/MSMCF-7Molecular dockingNetwork pharmacologyOleaceae

Identifiers

PMID37210476
PMCPMC10199617
OpenAlexW4377137332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.