Evidence map›Paper›PMID 37210309›Full record

ArticleVaccine2023

VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe.

Jon Salmanton-García, Pauline Wipfler, Paula Valle-Simón, Christina Merakou, Ioannis Kopsidas, Ullrich Bethe, Angela Steinbach, Orly Spivak, Lenka Součková, Maria Amélia Mendonça and 36 more

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 20 countries.

Jon Salmanton-GarcíaUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
Pauline WipflerUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
Paula Valle-SimónHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain; Servicio Madrileño de Salud, Madrid, Spain.
Christina MerakouCollaborative Center for Clinical Epidemiology and Outcomes Research (CLEO), Athens, Greece.
Ioannis KopsidasCollaborative Center for Clinical Epidemiology and Outcomes Research (CLEO), Athens, Greece.
Ullrich BetheUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
Angela SteinbachUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
Orly SpivakMinistry of Health of Israel, Jerusalem, Israel.
Lenka SoučkováMasaryk University, Brno, Czech Republic.
Maria Amélia MendonçaCentro Hospitalar Universitário do Porto, Porto, Portugal.
Markela KoniordouCollaborative Center for Clinical Epidemiology and Outcomes Research (CLEO), Athens, Greece.
Margot HellemansUniversiteit Antwerpen, Faculty of Medicine and Health Science, VAXINFECTIO, Centre of Evaluation of Vaccination, Antwerp, Belgium.
Jesus Frías-IniestaHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain; Servicio Madrileño de Salud, Madrid, Spain.
Ruth Joanna DavisUniversity of Verona, Infectious Diseases Division, Department of Diagnostic and Public Health, Verona, Italy.
Imre BartaNational Koranyi Institute for Pulmonology, Budapest, Hungary.
Anna Maria AzziniUniversity of Verona, Infectious Diseases Division, Department of Diagnostic and Public Health, Verona, Italy.
Helena H AsklingKarolinska University Hospital, Stockholm, Sweden.
Christos D ArgyropoulosEuropean University of Cyprus, Nicosia, Republic of Cyprus.
Elena Álvarez-BarcoUniversity College Dublin, National University of Ireland, Dublin, Ireland.
Murat AkovaHaceteppe University, Ankara, Turkey.
Marc M J BontenJulius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Miriam Cohen-KandliMinistry of Health of Israel, Jerusalem, Israel.
Rebecca Jane CoxUniversity of Bergen, Bergen, Norway.
Robert FlisiakDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Białystok, Poland.
Petr HusaMasaryk University, Brno, Czech Republic.
Ligita JancorieneInstitute of Clinical Medicine, Medical Faculty, Vilnius University, Vilnius University Hospital Santaros klinikos, Vilnius, Lithuania.
Alena KoscalovaBiomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
Odile LaunayInstitut National de la Santé et de la Recherche Médicale-ANRS Maladies Infectieuses Émergentes, Paris, France.
Jens LundgrenCentre of Excellence for Health, Immunity and Infections (CHIP), Rigshospitalet, Copenhagen, Denmark.
Patrick MallonUniversity College Dublin, National University of Ireland, Dublin, Ireland.
Laura MarquesCentro Hospitalar Universitário do Porto, Porto, Portugal.
Pontus NauclérKarolinska University Hospital, Stockholm, Sweden.
Jordi OchandoCentro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain.
Zoi-Dorothea PanaEuropean University of Cyprus, Nicosia, Republic of Cyprus.
Evelina TacconelliUniversity of Verona, Infectious Diseases Division, Department of Diagnostic and Public Health, Verona, Italy.
Krisztina TóthNational Koranyi Institute for Pulmonology, Budapest, Hungary.
Sven TrelleUniversitaet Bern, Bern, Switzerland.
Pierre van DammeUniversiteit Antwerpen, Faculty of Medicine and Health Science, VAXINFECTIO, Centre of Evaluation of Vaccination, Antwerp, Belgium.
Theoklis E ZaoutisCollaborative Center for Clinical Epidemiology and Outcomes Research (CLEO), Athens, Greece.
Markus ZeitlingerMedizinische Universität Wien, Vienna, Austria.
Kerstin AlbusUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
Fiona A StewartUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
Sanne H I HofstraatUniversity Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Patricia Bruijning-VerhagenUniversity Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Oliver A CornelyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany. Electronic address: Oliver.Cornely@uk-koeln.de.
VACCELERATE Consortium. Electronic address: trialsites@vaccelerate.eu
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEUniversity of Cologne · DEUniversity of Verona · ITEuropean University Cyprus · CYIsrael Ministry of Health · ILKarolinska University Hospital · SEMadrid Health Service · ESMasaryk University · CZMedical University of Vienna · ATOrszágos Korányi Tbc és Pulmonológiai Intézet · HUUniversity College Dublin · IEUniversity Medical Center Utrecht · NLUniversity of Antwerp · BEBiomedical Research Center of the Slovak Academy of Sciences · SKCentre of Excellence for Health, Immunity and Infections · DKCentro Hospitalar do Porto · PTDüsseldorf University Hospital · DEHacettepe University · TRInserm · FRInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe inconsistent European vaccine trial landscape rendered the continent of limited interest for vaccine developers. The VACCELERATE consortium created a network of capable clinical trial sites throughout Europe. VACCELERATE identifies and provides access to state-of-the-art vaccine trial sites to accelerate clinical development of vaccines.

methodsLogin details for the VACCELERATE Site Network (vaccelerate.eu/site-network/) questionnaire can be obtained after sending an email to. Interested sites provide basic information, such as contact details, affiliation with infectious disease networks, main area of expertise, previous vaccine trial experience, site infrastructure and preferred vaccine trial settings. In addition, sites can recommend other clinical researchers for registration in the network. If directly requested by a sponsor or sponsor representative, the VACCELERATE Site Network pre-selects vaccine trial sites and shares basic study characteristics provided by the sponsor. Interested sites provide feedback with short surveys and feasibility questionnaires developed by VACCELERATE and are connected with the sponsor to initiate the site selection process.

resultsAs of April 2023, 481 sites from 39 European countries have registered in the VACCELERATE Site Network. Of these, 137 (28.5 %) sites have previous experience conducting phase I trials, 259 (53.8 %) with phase II, 340 (70.7 %) with phase III, and 205 (42.6 %) with phase IV trials, respectively. Infectious diseases were reported as main area of expertise by 274 sites (57.0 %), followed by any kind of immunosuppression by 141 (29.3 %) sites. Numbers are super additive as sites may report clinical trial experience in several indications. Two hundred and thirty-one (47.0 %) sites have the expertise and capacity to enrol paediatric populations and 391 (79.6 %) adult populations. Since its launch in October 2020, the VACCELERATE Site Network has been used 21 times for academic and industry trials, mostly interventional studies, focusing on different pathogens such as fungi, monkeypox virus, Orthomyxoviridae/influenza viruses, SARS-CoV-2, or Streptococcus pneumoniae/pneumococcus.

conclusionsThe VACCELERATE Site Network enables a constantly updated Europe-wide mapping of experienced clinical sites interested in executing vaccine trials. The network is already in use as a rapid-turnaround single contact point for the identification of vaccine trials sites in Europe.

Indexed as

COVID-19OrthomyxoviridaeVaccinesAdultChildEuropeHumansSARS-CoV-2VaccinesClinical networkPandemic preparednessRegistrySARS-CoV-2SiteVaccine trial

Identifiers

PMID37210309
PMCPMC10194816
OpenAlexW4377047655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.