Evidence map›Paper›PMID 37209936›Full record

ArticleDevelopmental biology2023

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.

Robert E Van Sciver, Alyssa B Long, Harrison G Katz, Eduardo D Gigante, Tamara Caspary

Open access · greenAbstract read
In one paragraph

Article in Developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Ciliary ARL13B Is Essential for Vision and Morphogenesis of Cone Outer Segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. ARL13B-Cerulean rescuesbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robert E Van SciverDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA. Electronic address: rvansci@emory.edu.
Alyssa B LongDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA. Electronic address: abushey@emory.edu.
Harrison G KatzDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA; Department of Biology, Brown University, Providence, RI, 02912, USA. Electronic address: harrison_g_katz@brown.edu.
Eduardo D GiganteDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA; Graduate Program in Neuroscience, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA; Department of Biology, Georgia Institute of Technology, Atlanta, GA, 30332, USA. Electronic address: egigante3@gatech.edu.
Tamara CasparyDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA. Electronic address: tcaspar@emory.edu.
Emory University · USGeorgia Institute of Technology · US

Funding

IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Genetic Dissection of Signaling and CiliaR35GM148416 · NIGMS · EMORY UNIVERSITY · PI TAMARA J. CASPARY · 2023 to 2026
$2.1M
Genetic Dissection of Signaling and CiliaR35GM122549 · NIGMS · EMORY UNIVERSITY · PI CASPARY, TAMARA J. · 2017 to 2021
$2.0M
Mechanisms underlying Joubert syndrome related brain malformationsR01NS090029 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, CASPARY, TAMARA J. · 2015 to 2018
$1.9M
Summer Undergraduate Program in Emory Renal Research (SUPERR)R25DK101390 · NIDDK · EMORY UNIVERSITY · PI Jason Cobb, Jeanie Park · 2014 to 2026
$1.4M
Genetic dissection of ciliary ARL13B in kidney cystogenesisR01DK128902 · NIDDK · EMORY UNIVERSITY · PI CASPARY, TAMARA J. · 2022 to 2024
$688k
The critical ciliary role of ARL13B in kidney cystogenesisF32DK127848 · NIDDK · EMORY UNIVERSITY · PI VAN SCIVER, ROBERT E · 2020 to 2023
$286k
Defining the relationship of ciliary Arl13b and SmoothenedF31NS106755 · NINDS · EMORY UNIVERSITY · PI GIGANTE, EDUARDO D. · 2019 to 2020
$91k
NIDDK NIH HHS F32 DK127848NIDDK NIH HHS R01 DK128902NIDDK NIH HHS R25 DK101390NIGMS NIH HHS K12 GM000680NIGMS NIH HHS R35 GM122549NIGMS NIH HHS R35 GM148416NINDS NIH HHS F31 NS106755NINDS NIH HHS R01 NS090029NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

ARL13B is a small GTPase enriched in cilia. Deletion of Arl13b in mouse kidney results in renal cysts and an associated absence of primary cilia. Similarly, ablation of cilia leads to kidney cysts. To investigate whether ARL13B functions from within cilia to direct kidney development, we examined kidneys of mice expressing an engineered cilia-excluded ARL13B variant, ARL13B

Indexed as

KidneyKidney Diseases, CysticADP-Ribosylation FactorsAnimalsCiliaGuanine Nucleotide Exchange FactorsMiceADP-Ribosylation FactorsArl13b protein, mouseGuanine Nucleotide Exchange FactorsARL13BARL3CiliaGEFRenal cysts

Identifiers

PMID37209936
PMCPMC10330881
OpenAlexW4377030712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.