Evidence map›Paper›PMID 37209779›Full record

Trial reportBrain, behavior, and immunity2023

Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial.

Jesse C Stewart, Jay S Patel, Brittanny M Polanka, Sujuan Gao, John I Nurnberger, Krysha L MacDonald, Samir K Gupta, Robert V Considine, Richard J Kovacs, Elizabeth A Vrany and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jesse C StewartDepartment of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA. Electronic address: jstew@iupui.edu.
Jay S PatelDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Brittanny M PolankaDivision Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Sujuan GaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
John I NurnbergerDepartment of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Krysha L MacDonaldSandra Eskenazi Mental Health Center, Eskenazi Health, Indianapolis, IN, USA.
Samir K GuptaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Robert V ConsidineDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Richard J KovacsDivision of Cardiovascular Disease, Indiana University School of Medicine, Indianapolis, IN, USA.
Elizabeth A VranyFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Jessica BerntsonDr. Jessica Berntson Inc., Coquitlam, BC, Canada.
Loretta HsuehDepartment of Psychology, University of Illinois Chicago, Chicago, IL, USA.
Aubrey L ShellDepartment of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.
Bruce L RollmanCenter for Behavioral Health, Media, and Technology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christopher M CallahanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Health, Indianapolis, IN, USA.

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tamara S Hannon · 2015 to 2026
$17.4M
Modernized Collaborative Care to Reduce the Excess CVD Risk of Depressed PatientsR01HL122245 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI STEWART, JESSE C · 2015 to 2019
$2.6M
NHLBI NIH HHS R01 HL122245NIDDK NIH HHS P30 DK097512
6 · The paper itself

Abstract

Although depression is a risk and prognostic factor for cardiovascular disease (CVD), clinical trials treating depression in patients with CVD have not demonstrated cardiovascular benefits. We proposed a novel explanation for the null results for CVD-related outcomes: the late timing of depression treatment in the natural history of CVD. Our objective was to determine whether successful depression treatment before, versus after, clinical CVD onset reduces CVD risk in depression. We conducted a single-center, parallel-group, assessor-blinded randomized controlled trial. Primary care patients with depression and elevated CVD risk from a safety net healthcare system (N = 216, M

Indexed as

Cardiovascular DiseasesCognitive Behavioral TherapyAntidepressive AgentsBiomarkersDepressionFemaleHumansMaleMiddle AgedAntidepressive AgentsBiomarkersAutonomic dysfunctionCardiovascular diseaseClinical trialCollaborative careDepressionEndothelial dysfunctionInternet interventionsPlatelet activationSystemic inflammation

Identifiers

PMID37209779
PMCPMC10527905

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.