SynthesisHuman brain mapping2023
Hippocampus long-axis specialization throughout development: A meta-analysis.
Synthesis in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hippocampus long-axis specialization throughout development: A meta-analysis.Human brain mapping · 2023Pooled it
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Increasing representational capacity in the hippocampal-frontoparietal system underlies hierarchical development of temporal memory.Developmental cognitive neuroscience · 2026Review
- Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes.bioRxiv : the preprint server for biology · 2026Article
- Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.Communications biology · 2026Article
- Magnetic resonance imaging-based assessment of hippocampal glutamate and morphometric changes in preterm infants at term-equivalent age with low birth weight.Pediatric radiology · 2026Article
- Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression.Translational psychiatry · 2025Article
- Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study.Acta neuropathologica communications · 2025Article
- Early functional organization of the anterior and posterior hippocampus in the fetal brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Early life stress impairs hippocampal subfield myelination.Communications biology · 2025Article
- Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The developing hippocampus: Microstructural evolution through childhood and adolescence.bioRxiv : the preprint server for biology · 2024Article
- Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions.Brain imaging and behavior · 2024Article
- Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Connectivity of the right cerebello-left hippocampal circuit across adulthood.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human adult hippocampus can be subdivided into the head, or anterior hippocampus and its body and tail, or posterior hippocampus, and a wealth of functional differences along the longitudinal axis have been reported. One line of literature emphasizes specialization for different aspects of cognition, whereas another emphasizes the unique role of the anterior hippocampus in emotional processing. While some research suggests that functional differences in memory between the anterior and posterior hippocampus appear early in development, it remains unclear whether this is also the case for functional differences in emotion processing. The goal of this meta-analysis was to determine whether the long-axis functional specialization observed in adults is present earlier in development. Using a quantitative meta-analysis, long-axis functional specialization was assessed using the data from 26 functional magnetic resonance imaging studies, which included 39 contrasts and 804 participants ranging in age from 4 to 21 years. Results indicated that emotion was more strongly localized to the anterior hippocampus, with memory being more strongly localized to the posterior hippocampus, demonstrating long-axis specialization with regard to memory and emotion in children similar to that seen in adults. An additional analysis of laterality indicated that while memory was left dominant, emotion was processed bilaterally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.