Evidence map›Paper›PMID 37209283›Full record

ArticleProtein science : a publication of the Protein Society2023

Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds.

Vijay Kumar, Jacob Boorman, William J Greenlee, Ximin Zeng, Jun Lin, Focco van den Akker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Vijay KumarDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Jacob BoormanDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
William J GreenleeMedChem Discovery Consulting, LLC, Teaneck, New Jersey, USA.
Ximin ZengDepartment of Animal Science, University of Tennessee, Knoxville, Tennessee, USA.
Jun LinDepartment of Animal Science, University of Tennessee, Knoxville, Tennessee, USA.
Focco van den AkkerDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · USUniversity of Tennessee at Knoxville · USMed Discovery (Switzerland) · CH

Funding

Small molecule inhibitors of lytic transglycosylase to potentiate beta-lactam antibioticsR21AI148875 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI VAN DEN AKKER, FOCCO · 2020 to 2021
$451k
NIAID NIH HHS R21 AI148875
6 · The paper itself

Abstract

Bacterial lytic transglycosylases (LTs) contribute to peptidoglycan cell wall metabolism and are potential drug targets to potentiate β-lactam antibiotics to overcome antibiotic resistance. Since LT inhibitor development is underexplored, we probed 15 N-acetyl-containing heterocycles in a structure-guided fashion for their ability to inhibit and bind to the Campylobacter jejuni LT Cj0843c. Ten GlcNAc analogs were synthesized with substitutions at the C1 position, with two having an additional modification at the C4 or C6 position. Most of the compounds showed weak inhibition of Cj0843c activity. Compounds with alterations at the C4 position, replacing the -OH with a -NH

Indexed as

Campylobacter jejuniPeptidoglycanGlycosyltransferasesProtein BindingGlycosyltransferasesmurein transglycosylasePeptidoglycanbulgecin AGlcNAc saccharide bindingpeptidoglycan metabolismprotein crystallographysoluble lytic transglycosylasestructure-based inhibitor designβ-lactam antibiotic potentiation

Identifiers

PMID37209283
PMCPMC10273340
OpenAlexW4377138045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.