Evidence map›Paper›PMID 37209203›Full record

ArticleGeroScience2023

DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation.

Matyas Jokai, Ferenc Torma, Kristen M McGreevy, Erika Koltai, Zoltan Bori, Gergely Babszki, Peter Bakonyi, Zoltan Gombos, Bernadett Gyorgy, Dora Aczel and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  3. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 5 countries.

Matyas JokaiResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Ferenc TormaResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Kristen M McGreevyDepartment of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Erika KoltaiResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Zoltan BoriResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Gergely BabszkiResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Peter BakonyiResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Zoltan GombosResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Bernadett GyorgyResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Dora AczelResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Laszlo TothResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Peter OsvathResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Marcell FridvalszkyResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Timea TeglasResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Aniko PosaInterdisciplinary Excellence Center, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6700, Szeged, Hungary.
Sylwester KujachDepartment of Physiology, Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland.
Robert OlekDepartment of Athletics, Strength and Conditioning, Poznań University of Physical Education, Poznań, Poland.
Takuji KawamuraFaculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.
Yasuhiro SekiFaculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.
Katsuhiko SuzukiFaculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.
Kumpei TanisawaFaculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan.
Sataro GotoResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.
Csaba KerepesiInstitute for Computer Science and Control (SZTAKI), Eötvös Loránd Research Network, Budapest, Hungary.
Istvan BoldoghDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
Xueqing BaKey Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, Jilin, China.
Kelvin J A DaviesEthel Percy Andrus Gerontology Centre of the Leonard Davis School of Gerontology; Division of Molecular & Computational Biology, Department of Biological Sciences, of the Dornsife College of Letters, Arts, and Sciences; and Department of Biochemistry & Molecular Medicine of the USC Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089-0191, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Zsolt RadakResearch Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary. radak.zsolt@tf.hu.ORCID 0000-0003-1297-6804
Hungarian School Sport Federation · HUWaseda University · JPUniversity of California, Los Angeles · USGdansk University of Physical Education and Sport · PLInstitute for Computer Science and Control · HUNortheast Normal University · CNThe University of Texas Medical Branch at Galveston · USUniversity of Southern California · USUniversity of Szeged · HUUniversity of Tsukuba · JP

Funding

OXYGEN RADICAL TOXICITY AND RED CELL PROTEIN DEGRADATIONR01ES003598 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIES, KELVIN J. A. · 1988 to 2017
$5.7M
USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Oxygen Radical Toxicity and Protein DegradationR56ES003598 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIES, KELVIN J. A. · 2012 to 2012
$138k
NIA NIH HHS T32 AG052374NIA NIH HHS U01 AG060908NIEHS NIH HHS R01 ES003598NIEHS NIH HHS R56 ES003598NIH HHS 1U01AG060908NIH HHS # ES003598 # AG052374
6 · The paper itself

Abstract

DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33-88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO

Indexed as

DNA MethylationQuality of LifeAgingBiomarkersExerciseFemaleHumansMaleBiomarkersDNA methylationDNAmFitAgeRegular exerciseSlower agingSystemic adaptation

Identifiers

PMID37209203
PMCPMC10643800
OpenAlexW4377157702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.