ArticleCNS neuroscience & therapeutics2023
Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- 20 Hz tACS engages striatal THINs to enhance β-band synchrony and motor drive.Frontiers in neuroscience · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Orexin signalling in the nucleus accumbens promotes arousal from isoflurane anaesthesia and restores communication between the nucleus accumbens and frontal cortex.British journal of anaesthesia · 2025Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Targeted-Modified MultiTransm Microelectrode Arrays Simultaneously Track Dopamine and Cellular Electrophysiology in Nucleus Accumbens during Sleep-Wake Transitions.Research (Washington, D.C.) · 2025Article
- Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics.Frontiers in pharmacology · 2024Review
- Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2023Article
- Editorial: Neural circuits underlying general anesthetics mediated consciousness changes.Frontiers in neural circuits · 2023Article
- Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeneral anesthesia has long been used in clinical practice, but its precise pharmacological effects on neural circuits are not fully understood. Recent investigations suggest that the sleep-wake system may play a role in the reversible loss of consciousness induced by general anesthetics. Studies in mice have shown that microinjection of dopamine receptor 1 (D1R) agonists into the nucleus accumbens (NAc) promotes recovery from isoflurane anesthesia, while microinjection of D1R antagonists has the opposite effect. Furthermore, during the induction and maintenance of sevoflurane anesthesia, there is a significant decrease in extracellular dopamine levels in the NAc, which subsequently increases during the recovery period. These findings suggest the involvement of the NAc in the regulation of general anesthesia. However, the specific role of D1R-expressing neurons in the NAc during general anesthesia and the downstream effect pathways are still not well understood.
methodsIn order to analyze the impact of sevoflurane anesthesia on NAc
resultsOur findings revealed that sevoflurane administration led to the inhibition of NAc
conclusionThe NAc
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.