Evidence map›Paper›PMID 37208923›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.

Manbo Cai, Weijun Wu, Shengling Deng, Qiao Yang, Haibiao Wu, Haiyun Wang, Jiaxing Zhang, Qisheng Feng, Jianyong Shao, Yixin Zeng and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Manbo CaiDepartment of Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.ORCID 0000-0003-0235-0111
Weijun WuDepartment of Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Shengling DengDepartment of Anesthesia, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Qiao YangDepartment of Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Haibiao WuDepartment of Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Haiyun WangState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Jiaxing ZhangState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Qisheng FengState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Jianyong ShaoState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Yixin ZengState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Jianjun LiDepartment of Urological Surgical, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001,China.
University of South China · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoskeleton-associated protein 4 (CKAP4) acts as a key transmembrane protein that connects the endoplasmic reticulum (ER) to microtubule dynamics. Researchers have not examined the roles of CKAP4 in nasopharyngeal carcinoma (NPC). The study aimed at evaluating the prognostic value and metastasis-regulating effect of CKAP4 in NPC. CKAP4 protein could be observed in 86.36% of 557 NPC specimens but not in normal nasopharyngeal epithelial tissue. According to immunoblot assays, NPC cell lines presented high CKAP4 expression relative to NP69 immortalized nasopharyngeal epithelial cells. Moreover, CKAP4 was highly expressed at the NPC tumor front and in matched liver, lung, and lymph node metastasis samples. Furthermore, high CKAP4 expression reported poor overall survival (OS) and presented a positive relevance to tumor (T) classification, recurrence, and metastasis. According to multivariate analysis, CKAP4 could independently and negatively predict patients' prognosis. Stable knockdown of CKAP4 expression in NPC cells inhibited cell migration, invasion and metastasis

Indexed as

Nasopharyngeal NeoplasmsCadherinsCell Line, TumorCell MovementCytoskeletonEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMembrane ProteinsNasopharyngeal CarcinomaNeoplasm InvasivenessVimentinCadherinsCKAP4 protein, humanMembrane ProteinsVimentinCKAP4EMTmetastasisNasopharyngeal carcinomaprognosis

Identifiers

PMID37208923
PMCPMC10581166
OpenAlexW4377139704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.