ArticleArthritis research & therapy2023
Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion-tensor imaging study.
Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Two Neuroanatomical Subtypes in Fibromyalgia Patients: Distinct Morphological Patterns and Treatment Outcomes.CNS neuroscience & therapeutics · 2025Trial
- Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID: a pilot randomized clinical trial.Scientific reports · 2024Trial
- Article
- Programmed Cell Death Ligand 1 Is Essential for Electroacupuncture-Mediated Analgesia in the Cerebellum of Fibromyalgia Mice.Biomedicines · 2026Article
- Moving Toward Objective Diagnosis in Fibromyalgia: Emerging Biomarkers and Digital Phenotyping Tools.Biomedicines · 2026Review
- Cerebellar Tissue Properties Alterations in Fibromyalgia: A T1w/T2w Ratio Study.Human brain mapping · 2026Article
- Machine learning for the diagnosis of fibromyalgia based on magnetic resonance imaging.PloS one · 2026Article
- Clinical and neuroimaging correlates of disease related gait patterns in patients with multiple system atrophy cerebellar type.Scientific reports · 2025Article
- Diffusion tensor imaging of white matter integrity and pain-related outcomes in chronic nonspecific neck pain.Scientific reports · 2025Article
- An Imaging-Based Investigation of the Potential Relationship Between Trigeminal Nerve Microstructure, Paranasal Sinus Volumes, and Headache in Fibromyalgia.Journal of clinical practice and research · 2025Article
- Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.The international journal of neuropsychopharmacology · 2025Article
- The insula represents a key neurobiological pain hub in psoriatic arthritis.Arthritis research & therapy · 2025Article
- Application of machine learning in depression risk prediction for connective tissue diseases.Scientific reports · 2025Article
- Investigating the neural correlates of the left thalamus in women with fibromyalgia: A Granger causality and voxel-based morphometry approach.SAGE open medicine · 2025Article
- Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis.Journal of pain research · 2025Article
- Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis.Scientific reports · 2024Article
- Identification of texture MRI brain abnormalities on Fibromyalgia syndrome using interpretable machine learning models.Scientific reports · 2024Article
- Pressure pain threshold encode hyperalgesia or antinociception in fibromyalgia patients?Journal of rheumatic diseases · 2024Article
- Population Pharmacokinetic-Pharmacodynamic Analysis of a Reserpine-Induced Myalgia Model in Rats.Pharmaceutics · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have repeatedly found distinct brain morphometric changes in patients with fibromyalgia (FM), mainly affecting gray and white matter abnormalities in areas related to sensory and affective pain processing. However, few studies have thus far linked different types of structural changes and not much is known about behavioral and clinical determinants that might influence the emergence and progression of such changes.
methodsWe used voxel-based morphometry (VBM) and diffusion-tensor imaging (DTI) to detect regional patterns of (micro)structural gray (GM) and white matter (WM) alterations in 23 patients with FM compared to 21 healthy controls (HC), while considering the influence of demographic, psychometric, and clinical variables (age, symptom severity, pain duration, heat pain threshold, depression scores).
resultsVBM and DTI revealed striking patterns of brain morphometric changes in FM patients. Bilateral middle temporal gyrus (MTG), parahippocampal gyrus, left dorsal anterior cingulate cortex (dACC), right putamen, right caudate nucleus, and left dorsolateral prefrontal cortex (DLPFC) showed significantly decreased GM volumes. In contrast, increased GM volume was observed in bilateral cerebellum and left thalamus. Beyond that, patients displayed microstructural changes of WM connectivity within the medial lemniscus, corpus callosum, and tracts surrounding and connecting the thalamus. Sensory-discriminative aspects of pain (pain severity, pain thresholds) primarily showed negative correlations with GM within bilateral putamen, pallidum, right midcingulate cortex (MCC), and multiple thalamic substructures, whereas the chronicity of pain was negatively correlated with GM volumes within right insular cortex and left rolandic operculum. Affective-motivational aspects of pain (depressive mood, general activity) were related to GM and FA values within bilateral putamen and thalamus.
conclusionsOur results suggest a variety of distinct structural brain changes in FM, particularly affecting areas involved in pain and emotion processing such as the thalamus, putamen, and insula.
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