ArticleBMC pregnancy and childbirth2023
Copper and zinc deficiency to the risk of preterm labor in pregnant women: a case-control study.
Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta-Analysis.Journal of evidence-based medicine · 2025Pooled it
- Analysis of zinc and copper levels in very low birth weight infants using human milk additives: phase 1 trial findings.Jornal de pediatriaTrial
- Association of gestational weight gain with adverse pregnancy outcomes across body mass index categories for twins in China.Frontiers in reproductive health · 2026Article
- Levels of Cu, Zn, and Se in Maternal and Cord Blood in Normal and Pathological Pregnancies: A Narrative Review.International journal of molecular sciences · 2025Review
- Maternal iron and zinc and preterm labor risk: A nested case-control study based on the Lanzhou Birth Cohort Study (BBCS) in China.Asia Pacific journal of clinical nutrition · 2025Article
- Heavy Metal Exposure During Pregnancy and Its Association With Adverse Birth Outcomes: A Cross-Sectional Study.GeoHealth · 2025Article
- Copper homeostasis and pregnancy complications: a comprehensive review.Journal of assisted reproduction and genetics · 2025Review
- Article
- Review
- Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization.International journal of women's health · 2024Article
- Micronutrients in Food Supplements for Pregnant Women: European Health Claims Assessment.Nutrients · 2023Article
- Individual and combined association between nutritional trace metals and the risk of preterm birth in a recurrent pregnancy loss cohort.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study explored the relationship between maternal copper and zinc levels and preterm labor.
designThe design of the present study was a case-control. Two groups were matched in terms of early-pregnancy body mass index (BMI), pregnancy and childbirth rating, education level, income, and employment status. Blood samples were taken from mothers after meeting the inclusion criteria when admitted to the maternity ward to check copper and zinc serum levels. Demographic and midwifery data were also collected using a questionnaire and patient records. The data were analyzed in SPSS26 using independent-samples T-test, chi-square, Fisher exact test, and regression analysis, and the p < 0.05 was considered statistically significant.
settingBohloul Hospital in Gonabad, Iran.
participantsThe subjects were 86 pregnant women visiting the hospital in two cases (preterm delivery) and control (term delivery) groups.
resultsThe mean serum level of zinc in the case group (preterm delivery) (44.97 ± 13.06 µg/dl) was significantly lower than the control group (term) (52.63 ± 21.51 µg/dl), and the mean serum level of copper in the case group (149.82 ± 53.13 µg/dl) was significantly lower than the control group (183.97 ± 71.40 µg/dl).
conclusionAs the findings showed, copper and zinc serum levels in mothers with preterm delivery were significantly lower than mothers with term delivery, which shows the biological role of these elements in the pathogenesis of preterm delivery.
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