Evidence map›Paper›PMID 37208482›Full record

ArticleSurgical endoscopy2023

Perfusion assessment by fluorescence time curves in esophagectomy with gastric conduit reconstruction: a prospective clinical study.

J J Joosten, M D Slooter, R M van den Elzen, P R Bloemen, S S Gisbertz, W J Eshuis, F Daams, D M de Bruin, M I van Berge Henegouwen

Open access · hybridAbstract read
In one paragraph

Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Use of indocyanine green in thoracic surgery: a literature review.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2026
    Review
  8. Guiding esophagectomy with intraoperative NIR-II fluorescence video imaging and rapid computation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J J JoostenDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6381-8182
M D SlooterDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
R M van den ElzenCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
P R BloemenCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
S S GisbertzDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
W J EshuisDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
F DaamsCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
D M de BruinCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.
M I van Berge HenegouwenDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. m.i.vanbergehenegouwen@amsterdamumc.nl.
Dutch Cancer Society · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative perfusion assessment with indocyanine green fluorescence angiography (ICG-FA) may reduce postoperative anastomotic leakage rates after esophagectomy with gastric conduit reconstruction. This study evaluated quantitative parameters derived from fluorescence time curves to determine a threshold for adequate perfusion and predict postoperative anastomotic complications.

methodsThis prospective cohort study included consecutive patients who underwent FA-guided esophagectomy with gastric conduit reconstruction between August 2020 and February 2022. After intravenous bolus injection of 0.05-mg/kg ICG, fluorescence intensity was registered over time by PINPOINT camera (Stryker, USA). Fluorescent angiograms were quantitatively analyzed at a region of interest of 1 cm diameter at the anastomotic site on the conduit using tailor-made software. Extracted fluorescence parameters were both inflow (T

resultsOne hundred and three patients (81 male, 65.7 ± 9.9 years) were included, the majority of whom (88%) underwent an Ivor Lewis procedure. AL occurred in 19% of patients (n = 20/103). Both time to peak as T

conclusionThis study demonstrated quantitative parameters and identified a fluorescent threshold which could be used for intraoperative decision-making and to identify high-risk patients for anastomotic leakage during esophagectomy with gastric conduit reconstruction. A significant predictive value remains to be determined in future studies.

Indexed as

Anastomotic LeakEsophagectomyAnastomosis, SurgicalColoring AgentsFluorescein AngiographyHumansIndocyanine GreenMalePerfusionPostoperative ComplicationsProspective StudiesStomachColoring AgentsIndocyanine GreenAnastomotic leakageEsophagectomyFluorescence angiography (FA)Fluorescence time curvesIndocyanine green (ICG)

Identifiers

PMID37208482
PMCPMC10338581
OpenAlexW4377091136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.