Evidence map›Paper›PMID 37208432›Full record

ArticlePediatric research2023

Gene expression in the intestine of newborn piglets after hypoxia-reoxygenation.

Baukje M Dotinga, Mian Bao, Rønnaug Solberg, Ola D Saugstad, Jan B F Hulscher, Arend F Bos, Torsten Plösch, Elisabeth M W Kooi

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In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Baukje M DotingaDivision of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Mian BaoDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.bao@umcg.nl.
Rønnaug SolbergDivision of Pediatric and Adolescent Medicine, Department of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.
Ola D SaugstadDivision of Pediatric and Adolescent Medicine, Department of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.
Jan B F HulscherDivision of Pediatric Surgery, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Arend F BosDivision of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Torsten Plösch *Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Elisabeth M W Kooi *Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University of Groningen · NLUniversity of Oslo · NOUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn preterm infants, intestinal hypoxia may partly contribute to the pathophysiology of necrotizing enterocolitis through changes in gene expression. Splanchnic hypoxia can be detected with monitoring of regional splanchnic oxygen saturation (r

methodsForty-two newborn piglets were randomized to control or intervention groups. Intervention groups were subjected to hypoxia until they were acidotic and hypotensive. Next, they were reoxygenated for 30 min according to randomization, i.e., 21% O

resultsThe expression of selected genes was not significantly different between control and intervention groups. No associations between mean r

conclusionOur study suggests that hypoxia and reoxygenation cause reduced vascular adaptability, which seems to be associated with the upregulation of apoptosis and downregulation of inflammation. IMPACT: Our results provide important insight into the (patho)physiological significance of changes in the variability of r

Indexed as

HypoxiaInfant, PrematureAnimalsAnimals, NewbornDisease Models, AnimalGene ExpressionHumansInfant, NewbornInflammationIntestinesOxygenRandom AllocationSwineOxygen

Identifiers

PMID37208432
OpenAlexW4377097431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.