Evidence map›Paper›PMID 37208323›Full record

Trial reportNature communications2023

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients.

Felix Dewald, Martin Pirkl, Martha Paluschinski, Joachim Kühn, Carina Elsner, Bianca Schulte, Jacqueline Knüfer, Elvin Ahmadov, Maike Schlotz, Göksu Oral and 30 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 7 institutions in 1 country.

Felix DewaldInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Martin PirklInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.ORCID 0000-0002-6986-0813
Martha PaluschinskiInstitute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.ORCID 0000-0002-6899-3753
Joachim KühnInstitute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
Carina ElsnerInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45141, Essen, Germany.ORCID 0000-0001-6590-8413
Bianca SchulteInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID 0000-0003-1096-3751
Jacqueline KnüferInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Elvin AhmadovInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Maike SchlotzInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Göksu OralInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Michael BernhardEmergency Department, Medical Faculty and University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Mark MichaelEmergency Department, Medical Faculty and University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Maura LuxenburgerInstitute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Marcel AndréeInstitute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Marc Tim HenniesInstitute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
Wali HafeziInstitute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
Marlin Maybrit MüllerInstitute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
Philipp KümpersDivision of General Internal and Emergency Medicine, Nephrology, Hypertension and Rheumatology, Department of Medicine D, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
Joachim RisseCenter of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.ORCID 0000-0002-1671-8506
Clemens KillCenter of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
Randi Katrin ManegoldCenter of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
Ute von FrantzkiCenter of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
Enrico RichterInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Dorian EmmertInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Werner O Monzon-PosadasOccupational Medicine Department, University Hospital Bonn, 53127, Bonn, Germany.
Ingo GräffEmergency Department, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Monika KogejEmergency Department, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Antonia BüningInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Maximilian BaumInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Finn TeipelInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.ORCID 0000-0001-8672-7443
Babak MochtarzadehInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Martin WolffInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Henning GruellInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.ORCID 0000-0002-0725-7138
Veronica Di CristanzianoInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.ORCID 0000-0003-1604-8386
Volker BurstDepartment II of Internal Medicine: Nephrology, Rheumatology, Diabetes and General Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne, 50931, Cologne, Germany.
Hendrik StreeckInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Ulf DittmerInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45141, Essen, Germany.
Stephan LudwigInstitute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.ORCID 0000-0003-4490-3052
Jörg TimmInstitute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Florian KleinInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. florian.klein@uk-koeln.de.ORCID 0000-0003-1376-1792
University of Cologne · DEUniversity of Bonn · DEDüsseldorf University Hospital · DEEssen University Hospital · DEUniversity of Duisburg-Essen · DEUniversity Hospital Bonn · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid seroprevalence and serum neutralizing activity against Wu01, BA.4/5 and BQ.1.1 in a convenience sample of 1,411 patients receiving medical treatment in the emergency departments of five university hospitals in North Rhine-Westphalia, Germany, in August/September 2022. 62% reported underlying medical conditions and 67.7% were vaccinated according to German COVID-19 vaccination recommendations (13.9% fully vaccinated, 54.3% one booster, 23.4% two boosters). We detected Spike-IgG in 95.6%, Nucleocapsid-IgG in 24.0%, and neutralization against Wu01, BA.4/5 and BQ.1.1 in 94.4%, 85.0%, and 73.8% of participants, respectively. Neutralization against BA.4/5 and BQ.1.1 was 5.6- and 23.4-fold lower compared to Wu01. Accuracy of S-IgG detection for determination of neutralizing activity against BQ.1.1 was reduced substantially. We explored previous vaccinations and infections as correlates of BQ.1.1 neutralization using multivariable and Bayesian network analyses. Given a rather moderate adherence to COVID-19 vaccination recommendations, this analysis highlights the need to improve vaccine-uptake to reduce the COVID-19 risk of immune evasive variants. The study was registered as clinical trial (DRKS00029414).

Indexed as

COVID-19Antibodies, NeutralizingAntibodies, ViralBayes TheoremCOVID-19 VaccinesHumansImmunity, HumoralImmunoglobulin GSARS-CoV-2Seroepidemiologic StudiesVaccinationAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesImmunoglobulin G

Identifiers

PMID37208323
PMCPMC10199003
OpenAlexW4377115745

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.