Evidence map›Paper›PMID 37208303›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Sudden cardiac death after heart transplantation: a population-based study.

Guillaume Bonnet, Guillaume Coutance, Olivier Aubert, Victor Waldmann, Marc Raynaud, Anouk Asselin, Marie-Cécile Bories, Romain Guillemain, Patrick Bruneval, Shaida Varnous and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Review
  3. [Epidemiological characteristics of heart transplant recipients in Peru 2010-2020].Archivos peruanos de cardiologia y cirugia cardiovascular
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Guillaume BonnetUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.ORCID 0000-0002-3027-1771
Guillaume CoutanceUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.ORCID 0000-0003-4939-2175
Olivier AubertUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.
Victor WaldmannUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.ORCID 0000-0001-8057-1900
Marc RaynaudUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.
Anouk AsselinUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.ORCID 0000-0002-8235-5475
Marie-Cécile BoriesCardiology and Heart Transplant department, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Rue Leblanc, 75015 Paris, France.
Romain GuillemainCardiology and Heart Transplant department, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Rue Leblanc, 75015 Paris, France.ORCID 0000-0002-7207-9876
Patrick BrunevalPathology Department, Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris. Université de Paris, Paris, France.ORCID 0000-0002-2350-2914
Shaida VarnousDepartment of Cardiac and Thoracic Surgery, Cardiology Institute, Pitié-Salpeêtrière Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University Medical School, Paris, France.
Pascal LeprinceDepartment of Cardiac and Thoracic Surgery, Cardiology Institute, Pitié-Salpeêtrière Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University Medical School, Paris, France.
Paul AchouchCardiology and Heart Transplant department, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Rue Leblanc, 75015 Paris, France.ORCID 0000-0002-5807-6820
Eloi MarijonUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.ORCID 0000-0001-7227-3428
Alexandre LoupyUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.
Xavier JouvenUniversité de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, 75015 Paris, France.
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe epidemiology of sudden cardiac death (SCD) after heart transplantation (HTx) remains imprecisely described. We aimed to assess the incidence and determinants of SCD in a large cohort of HTx recipients, compared with the general population. METHODS AND

resultsConsecutive HTx recipients (n = 1246, 2 centres) transplanted between 2004 and 2016 were included. We prospectively assessed clinical, biological, pathologic, and functional parameters. SCD was centrally adjudicated. We compared the SCD incidence beyond the first year post-transplant in this cohort with that observed in the general population of the same geographic area (registry carried out by the same group of investigators; n = 19 706 SCD). We performed a competing risk multivariate Cox model to identify variables associated with SCD. The annual incidence of SCD was 12.5 per 1,000 person-years [95% confidence interval (CI), 9.7-15.9] in the HTx recipients cohort compared with 0.54 per 1,000 person-years (95% CI, 0.53-0.55) in the general population (P < 0.001). The risk of SCD was markedly elevated among the youngest HTx recipients with standardized mortality ratios for SCD up to 837 for recipients ≤30 years. Beyond the first year, SCD was the leading cause of death. Five variables were independently associated with SCD: older donor age (P = 0.003), younger recipient age (P = 0.001) and ethnicity (P = 0.034), pre-existing donor-specific antibodies (P = 0.009), and last left ventricular ejection fraction (P = 0.048).

conclusionHTx recipients, particularly the youngest, were at very high risk of SCD compared with the general population. The consideration of specific risk factors may help identify high-risk subgroups.

Indexed as

Heart TransplantationVentricular Function, LeftDeath, Sudden, CardiacHumansRisk FactorsStroke VolumeDonor-specific antibodiesHeart transplantationSudden cardiac death

Identifiers

PMID37208303
PMCPMC10198773
OpenAlexW4377116051

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.